%0 Journal Article
%T Long-Term Persistent Absolute Insulin Secretion Deficiency in Diabetes Induced by Immune Checkpoint Inhibitors
%A Moctar Bah
%A Clara Bouch¨¦
%A Jean-Fran£¿ois Gautier
%J Open Journal of Endocrine and Metabolic Diseases
%P 227-233
%@ 2165-7432
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojemd.2023.1312017
%X Immune checkpoint inhibitors are today an immense hope in the management
of cancers. However, since their widespread use, many cases of
insulin-requiring diabetes appearing suddenly, as fulminant diabetes have been
reported. Here, we describe 4 cases that occurred at different times after the
beginning of immune checkpoint inhibitor therapy with Nivolumab alone or
associated with Ipilimumab. There are 3 cases of newly diagnosed diabetes and 1
case of known type 2 diabetes formerly quite well balanced with Metformin. The
clinical and biological characteristics of these patients are quite similar.
They were all insulin-requiring at the discovery of diabetes and remained so
throughout their follow-up. This type of diabetes which looks like type 1
diabetes seems rather to be a new entity.
%K Immune Checkpoint Inhibitors
%K Nivolumab
%K Ipilimumab
%K Fulminant Diabetes
%K Insulin-Requiring Diabetes
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=130074