%0 Journal Article
%T Antibiotics Resistance of Urogenital Mycoplasma in Sexually Active Women Attending Gynecologic Consultation in Douala (Cameroon)
%A Jean Pierre Nda Mefo¡¯o
%A Rosa Fetue Notio
%A Fulbert Mangala Nkwele
%A Grace Dalle Ngondi
%A Emmanuel Roddy Mengue
%A Elodie Ngo Malabo
%A Charlotte Tchente Nguefack
%A C¨¦cile Okalla Ebongue
%A Th¨¦ophile Nana Njamen
%J Advances in Microbiology
%P 559-570
%@ 2165-3410
%D 2023
%I Scientific Research Publishing
%R 10.4236/aim.2023.1312036
%X <b>Introduction:</b> Mycoplasmas are bacteria commonly found in the commensal flora of humans and can occasionally be pathogenic. The population and the geographical area determine their susceptibility to various antibiotics. <b>Methodology:</b> We carried out a cross-sectional study from January to June 2022 at the Douala General Hospital. All women who were sexually active and willing to participate were included. Endo-cervical swabbing was used to collect the samples. Culture and antibiotic susceptibility testing were performed in a liquid medium using Mycoplasma-SystemPlus Gallery (Liofilchem). All samples that degraded urea (threshold &gt; 10<sup>3</sup> for <i>Ureaplasma urealyticum</i>) and arginine (threshold &gt; 10<sup>4</sup> for <i>Mycoplasma hominis</i>) were deemed positive. <b>Results:</b> A total of 107 women with a median age of 33 ¡À 8.3 years and a predominance of 30-40 years (41.1%) were included. The frequency of mycoplasma infection was 73.8% with 34.1%, 11.4% and 54.4% for <i>Ureaplasma urealyticum</i>, <i>Mycoplasma hominis</i> and co-infection respectively. Resistance rates to Minocycline were low, 1.3% for <i>Ureaplasma urealyticum</i> and 3.7% for co-infection; for Pefloxacin the resistance rates were 3.7% (<i>Ureaplasma urealyticum</i>, <i>Mycoplasma hominis</i>) and 22.8% (co-infection). <i>Ureaplasma urealyticum</i> had a resistance rate of 3.7% for Erythromycin, 1.3% for Clarithromycin and 5% for Azithromycin. There was no significant correlation between risk factors and infection. Vaginal cleansing and the development of resistance in mycoplasma infection were found to be significantly correlated (OR = 6.915 [1.52 - 31.55]; (p = 0.013)). <b>Conclusion:</b> Minocycline was the most active antibiotic and <i>Ureaplasma urealyticum</i> was the species with the lowest rate of resistance. Antibiotic resistance was more common in co-infected people than mono-infected. Antibiotic resistance was independently correlated with vaginal douching.
%K Urogenital Mycoplasma
%K Sexually Active Women
%K Douala
%K Cameroon
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=129986