%0 Journal Article
%T Aminated (Cyclopropylmethyl)Phosphonates: Synthesis and Anti-Pancreatic Cancer Activity
%A Abed Al Aziz Al Quntar
%A Ibrahim Abasy
%A Hasan Dweik
%A Michel Maffei
%A Valery M. Dembitsky
%J International Journal of Organic Chemistry
%P 129-136
%@ 2161-4695
%D 2023
%I Scientific Research Publishing
%R 10.4236/ijoc.2023.134010
%X Buoyed by the extensive research on the wide-range biological activities of aminophosphonates, a novel class of aminated (cyclopropylmethyl)phosphor-nates compounds was synthesized from diethyl ((1-(3-chloropropyl)cyclopropyl)methyl)phosphonate and various amines in the presence of HunigĄ¯s base. Upon biological activity screening these compounds demonstrated encouraging anti-pancreatic cancer properties at low micromolar concentrations.
%K Phosphonates
%K Aminophosphonates
%K Pancreatic Cancer
%K Cancer
%K Cyclopropylphosphonates
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=129929