%0 Journal Article
%T Immunization against Hepatitis B Virus: Serological Status of West African Populations Residing in Cotonou (Benin) and Dakar (Senegal)
%A Comlan Jerome Gaston Montcho
%A Pelagie Mougola Bissiengou
%A L¨¦opold Ngor Sene
%A Khadidiatou Sarr Fall
%A Ousseynou Boye
%A Moustapha Mbow
%A Babacar Mbengue
%A Alioune Dieye
%A Maguette Sylla Niang
%J Open Journal of Immunology
%P 99-108
%@ 2162-4526
%D 2023
%I Scientific Research Publishing
%R 10.4236/oji.2023.134007
%X <strong>Background:</strong> <span style=\"font-family:;\" \"=\"\">According to WHO estimates,
by 2022 over 296 million people are living with chronic hepatitis B virus (HBV)
infection, and over 820,000 have died from complications. In sub-Saharan
African countries such as Benin and Senegal, few research studies have
addressed the issue of HBV immunization. <b>Objective: </b>The main objective
of this study was to evaluate immunization against the hepatitis B virus in
populations residing in Cotonou and Dakar by titrating anti-HBs antibodies (Ab)
and detecting total anti-HBc immunoglobulins (Ig). <b>Materials and Methods: </b>This
was a prospective, descriptive, analytical study of two West African
populations recruited in Dakar at the Laboratory of Medical Biology (LBM) of
the General Hospital Idrissa Pouye (HOGIP) and in Cotonou at the LBMs of the
health centres of the Cotonou archdiocese. HBsAg-negative patients constituted
our study population. The study</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\">took place in November-December 2019 for Dakar and
February-March 2020 for Cotonou. Anti-HBs antibodies were tested and titrated.
In the event of anti-HBs positivity, total anti-HBc was determined. A
microparticle chemiluminescence immunoassay was used for marker determination.
The detection threshold was 2.50 IU/L for anti-HBs. Excel and IBM SPSS
Statistics software were used for data analysis. Subjects</span><span style=\"font-family:;\" \"=\"\">¡¯</span><span style=\"font-family:;\" \"=\"\"> sociodemographic characteristics were collected
using a questionnaire, as was knowledge of their vaccination status. The study
was approved by the ethics committees in Benin and Senegal. <b>Results: </b>A
total of 394 HBs antigen-negative participants were recruited: 205 in Cotonou
and 189 in Dakar. The population was predominantly female, with 65.36% (N = 134)
and 57.14% (N = 108) women in Cotonou and Dakar respectively. The median age of
participants was 29 years in Cotonou, with extremes of 10 and 65 years, versus
39 years in Dakar, with extremes of 6 and 93 years. Some participants claimed
to be unaware of their vaccination status: 33.17% in Cotonou and 56.61% in
Dakar. The total prevalence of anti-HBs-positive subjects was 88.78% (N = 182)
in Cotonou and 98.41% (N = 186) in Dakar. In Cotonou (N = 205), 35.61% (N = 73)
of subjects had protective anti-HBs levels between 11.60 IU/L and 10,000 IU/L.
In Dakar, 61.38% (N = 116) of subjects had protective HBV immunity, with
anti-HBs titres ranging from 10.30 IU/L to 11357
%K HBV
%K Anti-HBs
%K Anti-HBc-Cotonou-Dakar
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=129619