%0 Journal Article
%T 单核细胞/高密度脂蛋白胆固醇比值与早期糖尿病肾病的相关性研究<br>Correlation between Monocyte/High-Density Lipoprotein Cholesterol Ratio and Early Diabetic Nephropathy
%A 王玉金
%A 侯志梅
%J Advances in Clinical Medicine
%P 17803-17809
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.13112496
%X 目的探讨新型炎性指标单核细胞/高密度脂蛋白胆固醇比值与EDN的相关性。方法选取2020年12月~2023年7月新疆医科大学第二附属医院收治的62例早期糖尿病肾病患者作为EDN组，另取同期在该院就诊的62例2型糖尿病患者作为对照组。采用全自动血细胞分析仪进行血常规测定，用全自动生化分析仪测定常规生化指标，根据血常规和血脂指标计算出MHR (单核细胞/高密度脂蛋白胆固醇)。采用Spearman法分析MHR与EDN的相关性。结果：EDN组MHR、甘油三酯、血肌酐、尿素氮、单核细胞计数、尿酸、同型半胱氨酸均高于对照组(P &lt; 0.05)。高密度脂蛋白胆固醇低于对照组(P &lt; 0.05)。Spearman相关性分析结果显示，MHR与EDN呈正相关(r = 0.303, P = 0.001)。<br />
Objective: To investigate the correlation between the ratio of monocyte/high-density lipoprotein cholesterol and EDN. Methods: A total of 62 patients with early diabetic nephropathy admitted to the Second Affiliated Hospital of Xinjiang Medical University from December 2020 to July 2023 were selected as the EDN group, and 62 patients with type 2 diabetes admitted to the hospital during the same period were selected as the control group. Blood routine was determined by automatic blood cell analyzer, routine biochemical indexes were determined by automatic biochemical analyzer, and MHR was calculated according to blood routine and lipid indexes. The correlation between MHR and EDN was analyzed by Pearson method. Results: The levels of triglyceride, serum creatinine, urea nitrogen, monocyte count, uric acid and homocysteine in EDN group were higher than those in con-trol group (P &lt; 0.05). The levels of MHR, triglycerides, blood creatinine, urea nitrogen, monocyte count, uric acid, and homocysteine in the EDN group were higher than those in the control group (P &lt; 0.05). High density lipoprotein cholesterol is lower than the control group (P &lt; 0.05). Pearson correlation analysis showed that MHR was positively correlated with EDN (r = 0.303, P = 0.001).
%K 早期糖尿病肾病，炎症，MHR<br>EDN
%K Inflammation
%K MHR
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=75481