%0 Journal Article
%T Prevalence and Risk Factors of Penicillinase-Type <i>¦Â</i>-Lactamase Producing <i>Neisseria gonorrhoeae</i> Isolated from Patients Attending Health-Facilities in Yaounde, Cameroon
%A C¨¦cile Ingrid Djuikoue
%A Laurene Nzangem Doumene
%A Cedric Seugnou Nana
%A Joviale Magne Talla
%A Herman Koyouo Tagne
%A Blondelle Kitio Messeu
%A Farid Wega
%A Tobie Vianney Kamany Kamdem
%A Willy Yamdeu Djonkouh
%A Ghandhi Fossouo Ndieffouo
%A Carole Tayimetha
%A Benjamin D. Thumamo Pokam
%A Nicolas Antoine-Moussiaux
%J Open Journal of Medical Microbiology
%P 220-233
%@ 2165-3380
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojmm.2023.133018
%X <b><span style=\"font-size:10.0pt;font-family:&quot;\">Background and Objectives: </span></b><span style=\"font-size:10.0pt;font-family:&quot;\">Mitigation of antibiotic resistant</span><span style=\"font-size:10.0pt;font-family:&quot;\"> </span><i><span style=\"font-size:10.0pt;font-family:&quot;\">Neisseria gonorrhoeae </span></i><span style=\"font-size:10.0pt;font-family:&quot;\">has become a priority due to considerable health and economical
disabilities it generates. In order to tackle the emergence of resistant <i>Neisseria gonorrhoeae</i>, this study aimed
to determine the prevalence and risk factors of penicillinase type <i>¦Â</i>-lactamase-producing <i>Neisseria gonorrheae</i></span><i><span style=\"font-size:10.0pt;font-family:&quot;\"> </span></i><span style=\"font-size:10.0pt;font-family:&quot;\">among patients consulting for genital infectious disorders in two
health-facilities in Yaounde</span><span style=\"font-size:10.0pt;font-family:&quot;\">,</span><span style=\"font-size:10.0pt;font-family:&quot;\"> Cameroon.<i> </i><b>Materials and Method: </b>A
cross-sectional descriptive and analytical study was conducted over a 3-month
period, from July 2<sup>nd</sup> to October 2<sup>nd</sup>, 2022. Vaginal and
urethral secretions were collected. Biochemical identification tests were
performed on colonies grown on chocolate agar + <span>polyvitex using the Api NH gallery. The detection of penicillinases was
equally</span> performed using the API NH gallery and confirmed using the
antimicrobial susceptibility testing. The Minimum Inhibitory Concentrations of
some antibiotics were determined using the E-Test. <b>Results: </b>The results
showed that <span>out of the 198 patients sampled,
16 (8.08%) were positive for <i>Neisseria
gonorrhoeae</i>, among which 13/16 (81.25%) were penicillinase-type</span></span><span style=\"font-size:10.0pt;font-family:&quot;\"> </span><i><span style=\"font-size:10.0pt;font-family:&quot;\">¦Â</span></i><span style=\"font-size:10.0pt;font-family:&quot;\">-lactamase producers.</span><span style=\"font-size:10.0pt;font-family:&quot;\"> Antimicrobial
susceptibility testing results showed high co-resistances <span>to antibiotics, mainly ciprofloxacin (100%),
nalidixic acid (92.31%) and</span> azith<span>romycin
(84.62%). Moreover, high Minimum Inhibitory Concentrations of ceftriaxone
(ranging from 6 to 24 mg/L) was observed toward <i>Neisseria gonorrhoeae</i> isolates. The risk factors</span></span><span style=\"font-size:10.0pt;font-family:&quot;\"> </span><span style=\"font-size:10.0pt;font-family:&quot;\">of
%K &lt
%K i&gt
%K Neisseria gonorrhoeae&lt
%K /i&gt
%K Antimicrobial Resistance
%K &lt
%K i&gt
%K ¦Â&lt
%K /i&gt
%K -Lactamase
%K Penicillinase
%K Cameroon
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=128116