%0 Journal Article
%T Insulin Sensitivity of Term Newborns Exposed <i>in Utero</i> to HIV and Antiretrovirals in Yaoundé
%A Francine Mendane Ekobena
%A Audrey Christance Donfack
%A Hortence Fouedjio
%A Suzanne Ngo Um Sap
%A Martine Claude Etoa Etoga
%A Mesmin Dehayem
%A Anne Boli Ongmeb
%A Gabriel Loni Ekali
%A Jean Claude Mbanya
%A Eug¨¨ne Sobngwi
%J Open Journal of Endocrine and Metabolic Diseases
%P 161-172
%@ 2165-7432
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojemd.2023.139013
%X Introduction: Antiretrovirals (ARVs) and the human
immunodeficiency virus (HIV) are implicated in the onset of insulin resistance.
They cross the placental barrier thereby inducing early modifications of the
fetal environment. The aim of our study was to assess insulin sensitivity in
full-term newborns exposed in utero to HIV and ARVs in Yaound¨¦. Materials
and Methods: We conducted an analytical cross-sectional study in 2
maternities in the city of Yaound¨¦ from November 2021 to June 2022. We
generated two groups of newborns (NBs): one
group born to HIV positive mothers on ARVs and the other control group born to HIV negative mothers. Clinical data from mothers and NBs
were collected. A homeostatic model assessment of insulin resistance (HOMA-IR)
like index with C peptide served to assess insulin sensitivity. We used the
Spearman correlation to measure the strength of
association between insulin sensitivity and the different variables. A p-value < 0.05 was considered statistically significant. Results: Of
70 neonates included, 35 were born to HIV positive mothers on ARVs and 35 to HIV negative mothers. The median age of HIV positive and negative mothers was 30 (27 - 32) and 34 (24 - 47) years, respectively (p = 0.791). The body mass index before pregnancy
as well as the average newborn weights were comparable
in both groups. The ARV protocol associating Tenofovir, Lamivudine,
Efavirenz was used by 97.1% of HIV positive mothers. In the exposed
%K Insulin Sensitivity
%K Newborns
%K Antiretrovirals
%K HIV
%K C Peptide
%K HOMA-IR
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127978