%0 Journal Article
%T 吸电子基修饰双键的二苯乙烯衍生物的合成及其生物活性综述<br>Review on the Synthesis and Biological Activities of Stilbene Derivatives Modified by Electron-Withdrawing Groups with Double Bonds
%A 马文晋
%A 邱海平
%J Journal of Organic Chemistry Research
%P 116-130
%@ 2330-524X
%D 2023
%I Hans Publishing
%R 10.12677/JOCR.2023.113012
%X 二苯乙烯类化合物广泛存在于自然界，有着丰富的药理活性，但是它们的生物利用率低，难以从自然界中大量获取，因此需要化学手段人工合成。通过不同基团对二苯乙烯骨架上芳基和双键的修饰可以得到不同活性的二苯乙烯衍生物。本文对近年来各种吸电子基团对二苯乙烯骨架上双键修饰的衍生物的合成方法及其生物活性进行了综述。<br />
Stilbenes exist widely in nature and have rich pharmacological activities. However, their bioavailability is low and it is difficult to obtain a large number of them from nature, so they need to be synthesized by chemical means. Stilbene derivatives with different activities can be obtained by modifying aryl groups and double bonds on stilbene skeleton. In this paper, the synthesis methods and biological activities of derivatives modified by various electron-absorbing groups on stilbene scaffolders in recent years are reviewed.
%K 二苯乙烯衍生物，吸电子基，合成，活性<br>Stilbene Derivative
%K Electron-Withdrawing Group
%K Synthesis
%K Activity
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=72264