%0 Journal Article
%T Evidence and Potential Antibacterial Mechanism of Chinese Traditional Medicine Compounds for the Development of <i>E. coli</i>
%A Yijun Lai
%A Yadan Huang
%J Chinese Medicine
%P 166-180
%@ 2151-1926
%D 2023
%I Scientific Research Publishing
%R 10.4236/cm.2023.143008
%X <span><i><span style=\"font-family:&quot;\">Astragalus membranaceus </span></i></span><span><span><span style=\"font-family:&quot;\">(<i>huangqi</i>), <i>Allium sativum </i>(<i>garlic</i>), <i>Cinnamomum cassia </i>(<i>cinnamon</i>), and <i>Dolichos
lablab L. </i>(<i>white hyacinth bean</i>)<i> </i>are the traditional Chinese herbs that </span></span></span><span><span><span style=\"font-family:&quot;\">were</span></span></span><span><span><span style=\"font-family:&quot;\"> used in prescriptions in treating diarrhea cause</span></span></span><span><span><span style=\"font-family:&quot;\">d</span></span></span><span><span><span style=\"font-family:&quot;\"> by
bacterial infection. These herbs are relatively safe for use and investigation.
This study aimed to investigate the effects of <i>Astragalus membrana<span>ceus</span></i><span>, <i>Allium
sativum</i>,<i> Cinnamomum cassia</i>,<i> </i>and <i>Dolichos
lablab L. on the metabolism of Escherichia coli </i>(<i>E. coli</i>)<i>. </i>The growth rate
of <i>E. coli</i> was monitored under the
influence of each herb, revealing that <i>Astragalus
membranaceus </i>and <i>Allium sativum </i>exhibited
significant antibacterial activity, whereas <i>Cinnamomum
cassia </i>and <i>Dolichos lablab L. </i>demonstrated
moderate inhibitory effects on <i>E. coli</i> growth. Further inhibition zone testing allowed for the evaluation of each herb¡¯s
potency and the number of generations required for <i>E. coli</i> to develop resistance. Additionally, the impact of the four
herbs on the expression of outer membrane protein A (OmpA) in <i>E. coli</i></span> was examined </span></span></span><span><span><span style=\"font-family:&quot;\">by </span></span></span><span><span><span style=\"font-family:&quot;\">using qPC<span>R. The findings revealed that <i>Astragalus membranaceus </i>acted as a
sustainable </span><span>bactericide by
inhibiting the growth and metabolism of <i>E.
coli</i> MG1655</span><span> through </span>the
suppression of OmpA expression. These results suggest that <i>Astragalus<span> membranaceus </span></i><span>has potential as a natural antimicrobial agent for
treating <i>E. coli</i> infections.
%K &lt
%K i&gt
%K E. coli&lt
%K /i&gt
%K Traditional Chinese Herbs
%K Antibacterial
%K OmpA
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127506