%0 Journal Article
%T Cardiac Manifestations with Chemotherapeutic Agents: 5 Fluorouracil-Induced Coronary Artery Vasospasm
%A Vignendra Ariyarajah
%A Mohamed S. Hameed
%A Mohamed Firdaus M. Mydeen
%A Guillermo J. Crespo
%J World Journal of Cardiovascular Surgery
%P 129-135
%@ 2164-3210
%D 2023
%I Scientific Research Publishing
%R 10.4236/wjcs.2023.138013
%X <span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">5</span><b><span style=\"font-family:Verdana;\">-</span></b><span style=\"font-family:Verdana;\">fluorouracil
(5-FU) is a fluorinated, pyrimidine analog, antineoplastic agent that is used
in the treatment of several solid organ cancers. Cardiotoxicity is uncommon but
life-threatening manifestations such as myocardial infarction may manifest
owing to 5-FU-induced coronary artery spasm. Administering smaller doses of the
drug, more frequently than not, decreases the risk of cardiotoxicity compared
to large doses or with continuous infusions. We present a case of ST-segment
elevation in a patient without known coronary artery </span><span style=\"font-family:Verdana;\">disease who had presented following continuous 5-FU infusion. Coronary</span><span style=\"font-family:Verdana;\"> angio</span><span style=\"font-family:Verdana;\">gram confirmed absence of coronary
artery disease and intravenous c</span><span style=\"font-family:Verdana;\">alcium channel blockers administration
was commensurate with the patient¡¯s improvement in symptoms. We discuss the
literature on 5-FU and its association with coronary artery spasm, and also
briefly review chemotherapy-ind</span><span style=\"font-family:Verdana;\">uced
cardiotoxicities to help better prepare internists and other p</span><span style=\"font-family:Verdana;\">rimary
health care providers to face similar challenges, particularly of the uncommon
but potentially life-threatening manifestations.
%K 5-Fluorouracil
%K Chemotherapeutic Agent
%K Cardiotoxicity
%K Vasospasm
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127464