%0 Journal Article
%T Clinical Presentation, Management and Materno-Fetal Outcome of Patients with HELLP Syndrome at the Yaoundé Gyneco-Obstetrics and Pediatric Hospital
%A Nzometia Crysantus Yimlefack
%A Foumane Pascal
%A Dohbit Julius Sama
%A Kenn Chi Ndi
%A Daniel Tarh Ketchen
%A Claude Hector Mbia
%A Robinson Enow Mbu
%J Open Journal of Obstetrics and Gynecology
%P 1432-1451
%@ 2160-8806
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojog.2023.138119
%X <strong>Background:</strong> <span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">HELLP (Hemolysis, Elevated Liver enzymes and Low Platelets) </span><span style=\"font-family:Verdana;\">syndrome is a common complication of severe
preeclampsia, with a high ma</span><span style=\"font-family:Verdana;\">ternal and perinatal mortality rate. Data on
HELLP syndrome is scanty in our setting. We sought to study the clinical
presentation, management, and materno-fetal outcome of patients with HELLP
syndrome at the Yaound¨¦ Gyneco-Obstetrics and Pediatric Hospital (YGOPH). </span><b><span style=\"font-family:Verdana;\">Methods:</span></b><span style=\"font-family:Verdana;\"> This was a cross-sectional, analytical study with a retrospective data
collection of patients, diagnosed with HELLP syndrome at the YGOPH between 1st
January 2020 and 31st July 2021. Data were analyzed using the software R
version 4.0.2. Results are presented as mean ¡À</span></span><span> </span><span style=\"font-family:Verdana;\">standard deviation, frequencies and percentages. P values &lt; 0.05 were
considered statistically significant.</span><span style=\"font-family:;\" \"=\"\"> <b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">Of 254
cases of severe preeclampsia, 17 developed HELLP syndrome, giving us a
frequency of 6.7%. One patient who presented with hepatitis B was excluded. The
mean age was 27.19</span></span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:Verdana;\">¡À</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\"><span style=\"font-family:Verdana;\">6.44 years. Most patients
(56.3%) had poor follow up during antenatal contacts. The most common symptom
was headache (93.8%). Most cases (56.3%) were diagnosed during post-partum,
prepartum (25.0%), and per partum (18.8%). Obstetrical management was done by
cesarean section (62.5%) and vaginal delivery (37.5%). Post-partum management
of HELLP syndrome consisted of antihypertensive medication, anticonvulsants,
sedatives, transfusion of blood and blood products, and fluid resuscitation. Of
the 50% of patients who presented with acute kidney injury, only 12.5% (1) were
referred for dialysis. Over 50% of our study participants presented severe
complications after delivery, but 43.8% recovered, while 56.2% finally died.
The fetal outcome was: still birth (31.2%), intra-uterine </span><span style=\"font-family:Verdana;\">growth restriction/low birth weight (12.5%), term
delivery (¡Ý37 weeks)
%K HELLP Syndrome
%K Clinical Presentation
%K Management
%K Maternal and Fetal Outcomes
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127376