%0 Journal Article
%T Pontocerebellar Progressive Multifocal Leukoencephalopathy. Radiological, Clinical, Histological and Immunohistochemical Findings in a Hematological Patient
%A Javier Ortiz
%A Juan Carlos Paniagua
%A Isidro Cavaco
%A Raquel Rivas
%A Andrea Jimenez
%A Luis Chinchilla
%A Elisa Mu£¿oz
%A Mar¨ªa Dolores Lude£¿a
%J Open Journal of Pathology
%P 177-183
%@ 2164-6783
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojpathology.2023.134018
%X <strong>Objective: </strong>To describe the radiological, histological and immunohistochemical findings in a case of Progressive Multifocal Leukoencephalopathy (PML) affecting the cerebellar peduncles in a patient with chronic lymphocytic leukemia. <strong>Patient and Methods:</strong> Magnetic Resonance Imaging (MRI), histological picture (H.E., Kluver-Barrera) and immunohistochemical picture (GFAP, neurofilaments, CD68, JC virus) were obtained. <strong>Results: </strong>1) Magnetic resonance imaging: Asymmetric and progressive lesions on middle cerebellar peduncles, that were hyperintense in T2/FLAIR, extended towards the pons, had no mass effect and were unmodified after intravenous contrast. 2) Histology: Marked reactive gliosis with cytopathic changes suggesting viral infection, plus demyelination areas with axonal preservation. 3) Immunohistochemistry: Marked positivity for viral (polyoma and JC virus) markers in glial cells showing cytopathic changes. <strong>Conclusions:</strong> The importance of histological and immunohistochemical diagnosis in everyday assistance; of the collaboration between clinicians, radiologists and pathologists; and the validity of postmortem studies as a key element for research and clinical quality assessment must be stressed.
%K Progressive Multifocal Leukoencephalopathy
%K JC Virus
%K Immunohistochemistry
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127156