%0 Journal Article
%T Immuno-Histochemical Profile of Breast Cancers at the General Hospital of Douala-Cameroon
%A Ekono Michel Roger Guy
%A Ngaha Yaneu Junie
%A Neng Humphry Tatah
%A Messakop Yannick
%A Azoumbou Mefant Th¨¦r¨¨se
%A Ze Ngbwa Mimi Flore
%A Essome Henri
%A Essola Basile
%A Engbang Jean-Paul
%A Tchente Nguefack Charlotte
%J Open Journal of Obstetrics and Gynecology
%P 1377-1388
%@ 2160-8806
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojog.2023.138115
%X Introduction: The aim of the study was to describe the
immunohistochemical aspects of breast cancers at Douala General Hospital</span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">,</span></span></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\"> Cameroon. Methodology: This was a descriptive study with retrospective data
collection, conducted from January 1</span><sup><span style=\"font-family:Verdana;\">st</span></sup><span style=\"font-family:Verdana;\"> 2010 and December 31</span><sup><span style=\"font-family:Verdana;\">st</span></sup><span style=\"font-family:Verdana;\"> 2019. It was focused on histologically proven breast cancers followed up at
Douala General Hospital. Results: We collected 285 cases of breast cancer, all
female, representing an annual frequency of 28.5 cases. The mean age of the
patients was 48</span></span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">¡À</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">13 years. The most frequent histological form was infiltrating ductal
carcinoma (83.9%), with grade II predominating (38.6%). Immunohistochemical
analyses were performed on 89 patients (31.23%). The triple-negative subtype
was the most common class (35.95%), followed by Luminal A (32.60); Human
Epidermal Receptor 2-class and Luminal B tumors were observed at a frequency of
13.48% each. Treatment consisted mainly of surgery (78.60%) combined with
chemotherapy (65.97%) and/or radiotherapy (63.16%). Hormonal treatment was used
in only 10.18% of patients. Targeted therapy was exceptional (4%). Conclusion:
Triple-negative phenotype is the most common. However, potentially
hormone-sensitive tumors account for almost half of all patients, who are
relatively young. Individualized treatments are rare. It is important to
systematize these analyses for all breast cancers, with a view to appropriate
management in our environment.
%K Breast Cancer
%K Immunohistochemistry
%K Douala General Hospital of Cameroon
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127165