%0 Journal Article %T Thalidomide Is an Adjunct Therapy for the Refractory Systemic Juvenile Idiopathic Arthritis Patients in a Tertiary Hospital Study %A Md. Taiyabur Rahman %A Mujammel Haque %A Farhana Faria %A Mohammed Mahbubul Islam %A Manik Kumar Talukder %A Mohammad Imnul Islam %A Shahana Akhter Rahman %J Open Journal of Rheumatology and Autoimmune Diseases %P 51-63 %@ 2164-005X %D 2023 %I Scientific Research Publishing %R 10.4236/ojra.2023.132005 %X Background: Systemic JIA (sJIA) is one of the subtypes of JIA, which is most difficult to treat among all JIA cases. About 50% of sJIA cases did not respond to traditional disease modifying anti-rheumatic drugs (DMARDs)—metho-trexate (MTX). Thalidomide is an immunomodulating and anti-inflammatory drug that induces sustained improvement of refractory sJIA cases. Objectives: To evaluate the efficacy of thalidomide in refractory sJIA patients. Methods: This was a prospective interventional study carried out in the Paediatric Rheumatology and Immunology follow-up clinic run by the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from January 2019 to July 2020. Twenty-five sJIA patients who were refractory to conventional DMARDs were included in this study. These patients were prescribed thalidomide at a dose of 3 - 5 mg/kg/day for six months and efficacy was assessed by using juvenile arthritis disease activity score (JADAS 27) at 12^th and 24^th weeks of treatment. Result: Active joint counts and ESR improvement were observed in 90.69%, 97.67% and 69.84%, 100% of sJIA patients respectively at 12^th and 24^th weeks of %K Juvenile Idiopathic Arthritis %K Thalidomide %K Refractory sJIA %U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127121