%0 Journal Article
%T Correlation of PSA Level and ISUP Grade Group with Scintigraphic Bone Metastases Detection in 36 Prostate Cancer Patients
%A Jean Sossa
%A Lionelle Fanou
%A Yao F¨¦licien Hounto
%A Dodji Magloire In¨¨s Yevi
%A Fred Jean-Martin Hodonou
%A D¨¦jinnin Josu¨¦ Georges Avakoudjo
%J Open Journal of Urology
%P 309-316
%@ 2160-5629
%D 2023
%I Scientific Research Publishing
%R 10.4236/oju.2023.138035
%X <strong>Background:</strong> We need population-specific clinical features that can predict bone metastases as an affordable therapeutic decision-making tool in newly diagnosed prostate cancer patients as scintigraphy or positron emission tomography are not available and as no such study had ever been performed in our country. <strong>Objective:</strong> To determine biologic and pathologic criteria that can predict the scintigraphic detection of bone metastases in our prostate cancer patients. <strong>Patients and Method:</strong> We analyzed with student¡¯s t test and logistic regression the PSA level, the ISUP grade and the scintigraphic data retrospectively collected in newly diagnosed prostate cancer patients. <strong>Results:</strong> In ten years, 36 prostate cancer patients were sent to the Korle Bu Teaching Hospital in Accra (Ghana) for bone scintigraphy (mean age = 63.9 years; 55.6%, 19.4% and 25.0% ISUP grade ¡Ü 2, 3 or ¡Ý4). Among 28 patients who had performed the bone scintigraphy, 6 (21.4%) presented bone metastases, 22 (78.6%) had no bone metastasis. The mean PSA level was 36.7ng/mL in the non-metastatic patients and 97.7 ng/mL in the metastatic patients. The difference in PSA level between the 2 groups was significative (<i>p</i> = 0.041). 63.6% of the non-metastatic cancers versus 16.7% of the metastatic cancers were ISUP grade 2 or less. Inversely, 36.4% of the non-metastatic cancers versus 83.3% of the metastatic cancers were ISUP grade 3 or more. The difference was significative in the ISUP grade 2 or less (<i>p</i> = 0.035), was significative in the ISUP grade group 3 or more (<i>p</i> = 0.035). Metastasis was more likely in prostate cancer patients with PSA equal 30 ng/mL or more and ISUP grade 3 or more (83.3%) than in prostate cancer patients with PSA less than 30 ng/mL and ISUP grade less than 3 (16.7%) [OR = 13.7; CI 95% (1.59; 31.0); <i>p</i> = 0.035]. <strong>Conclusion:</strong> The scintigraphic detection of bone metastases is low in patients with PSA &lt; 30 ng/mL and ISUP grade &lt; 3. This can be helpful in curative therapy decision making for prostate cancer when nuclear medicine or other metastases detection tools are lacking.
%K Metastasis
%K Prostate Cancer
%K Bone Scintigraphy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=127115