%0 Journal Article
%T Profile of Pituitary Adenomas in Senegal: Epidemiological, Clinical and Therapeutic Aspects about 241 Collected Cases
%A Di¨¦dhiou Demba
%A Diallo Ibrahima Man¨¦
%A Mbaye Maguette
%A Sow Djiby
%A Ndiaye Fama Mody
%A Ndour Michel Assane
%A Dieng Mouhamed
%A Gadji Fatou Kin¨¦
%A Thioye Elhadj Mamadou
%A Halim Charles
%A Ndao Cheikh
%A Matar Ndiaye
%A Boun Khatab Diouf
%A Sarr Anna
%A Ndour Mbaye Maimouna
%J Open Journal of Internal Medicine
%P 144-154
%@ 2162-5980
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojim.2023.133017
%X <strong>Introduction:</strong> in adults, adenomas are the most frequent causes of pituitary tumours. The objective was to characterize its epidemiological and clinical aspects, as well as its therapeutic modalities in Senegal. <strong>Methodology:</strong> this was a multicenter, retrospective, descriptive and analytical study carried out from the Senegalese register of pituitary adenomas (2008-2022). <strong>Results:</strong> 242 patients were collected with an average age of 42.4 ¡À 13 years and a sex ratio (M/F) of 0.91. The mean consultation time was 19.7 ¡À 23 months. The circumstances of discovery were pituitary apoplexy (11 cases, 4.54%), tumor syndrome (176 cases, 72.72%), gonadal manifestations (103 cases, 42.56%), dysmorphic syndrome (21 cases, 8.68%), hypercorticism (15 cases, 6.19%). Morphologically, it was a macroadenoma (197 cases, 81.40%), an extensive adenoma (22 cases, 9.10%). The hormonal profile was lactotropic hypersecretion (80 cases, 33.05%), somatotropic (13 cases, 5.39%), corticotropic (14 cases, 5.78%), mixed (9 cases, 3.71%). The factors significantly associated with prolactinoma were young age (p = 0.000), female sex (p = 0.000), long consultation delay (p = 0.000) and microadenoma (p = 0.001). Only arterial hypertension was associated with acromegaly (p = 0.000). We found a significant correlation between Cushing¡¯s disease and microadenomas (p = 0.000). Non-secreting adenomas were significantly associated with advanced age (p = 0.000), long delay in consultation (p = 0.000), male gender (p = 0.000), tumor syndrome (p = 0.001) and macroadenomas (p = 0.000). Pituitary surgery was effective in 173 patients (71.49%) including 166 cases (68.59%) by transphenoidal approach. Postoperative incidents were transient diabetes insipidus in 82 cases (47.39%), cerebrospinal fluid leak (20 cases, 11.56%). Death was observed in 18 patients in the entire series (7.44%). The latter had a tumor syndrome (88.88%), a macroadenoma (83.33%) and had undergone pituitary surgery (72.22%). <strong>Conclusion: </strong>pituitary pathology has become a reality with clinical and secretory polymorphism. The diagnostic delay explains the predominance of macroadenomas which are sources of pre and post-operative complications.
%K Pituitary Adenoma
%K Prognosis
%K Management
%K Senegal
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=126980