%0 Journal Article
%T 银黄清肺胶囊对鼻病毒作用的体外实验研究<br>Experimental Study on the Effect of Yinhuang Qingfei Capsule on Rhinovirus <em>in Vitro</em>
%A 屈金艳
%A 张奉学
%A 李艳波
%A 张婵娟
%A 赵立军
%A 文复权
%J Hans Journal of Biomedicine
%P 309-317
%@ 2161-8984
%D 2023
%I Hans Publishing
%R 10.12677/HJBM.2023.133036
%X 目的：观察银黄清肺胶囊对鼻病毒导致细胞病变的抑制作用。方法：以利巴韦林为对照药，接种鼻病毒R14型于HEL细胞，采用细胞病变抑制法(CPE)，观察银黄清肺胶囊体外对呼吸道鼻病毒作用。结果：银黄清肺胶囊在5.0 mg/mL和2.5 mg/mL浓度下均能完全抑制鼻病毒R14型对HEL细胞的病变，对鼻病毒R14型无预防作用，其疗效为抑制作用 &gt; 治疗作用 &gt; 预防作用。病毒直接杀伤作用试验中发现，5.0 mg/mL与1.0 mg/mL的银黄清肺胶囊对病毒的滴度无明显抑制作用。结论：银黄清肺胶囊对鼻病毒有较好的抑制作用，以及一定的治疗作用，其对病毒的抑制作用不是通过对病毒直接杀伤作用实现的，可能与改变受体细胞膜通道或与病毒竞争性结合膜受体，从而影响病毒的入侵过程以发挥抑制病毒复制的作用有关。<br />
Objective: To observe the inhibitory effect of Yinhuang Qingfei Capsule on cytopathic effect induced by Rhinovirus. Methods: Using ribavirin as a control drug, Rhinovirus R14 was inoculated into HEL cells, and cytopathic inhibition (CPE) was used to observe the effect of Yinhuang Qingfei Capsule on respiratory Rhinovirus in vitro. Yinhuang Qingfei Capsule can completely inhibit the pathological changes of Rhinovirus 14 to HEL cells at the concentrations of 5.0 mg/mL and 2.5 mg/mL, and has no preventive effect. The curative effect is inhibition &gt; therapeutic effect &gt; preventive effect. In the direct killing test of the virus, it was found that 5.0 mg/mL and 1.0 mg/mL of Yinhuang Qingfei Capsule had no significant inhibitory effect on the titer of the virus. Conclusion: Yinhuang Qingfei Capsule has a good inhibitory effect on Rhinovirus and a certain therapeutic effect. Its inhibitory effect on the virus is not achieved by direct killing of the virus, and may be related to changing the receptor cell membrane channel or competing with the virus to bind to the membrane receptor, thereby affecting the invasion process of the virus to play a role in inhibiting viral.
%K 银黄清肺胶囊，鼻病毒，体外<br>Yinhuang Qingfei Capsule
%K Rhinovirus
%K <em>In Vitro</em>
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=68875