%0 Journal Article
%T Evaluation of Glomerular Filtration Rate and Urinary Abnormalities in Children with Cancer before Chemotherapy
%A Mamadou Moustapha Diop
%A Aissata Barry
%A Ouo Ouo Koli¨¦
%A Emanuel Camara
%A Mohamed Lamine Diallo
%A Kaba Bangoura
%A Mamadou Aliou Doukour¨¦
%A P¨¦ Neabel Beimy
%A Dienab Diallo
%A Moustapha Kouyate
%A Mohamed Lamine Kaba
%J Open Journal of Pediatrics
%P 594-603
%@ 2160-8776
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojped.2023.134066
%X <p>
	<span style=\"font-family:Verdana;\"><b><span style=\"font-family:Verdana;\">Introduction: </span></b></span><span><span><span style=\"font-family:&quot;\"><span style=\"font-family:Verdana;\">Glomerular filtration is an
important elimination pathway for many types of chemotherapy. Accurate
estimation of glomerular filtration is essential in the management of children
with cancer. </span><b><span style=\"font-family:Verdana;\">Methodology: </span></b><span style=\"font-family:Verdana;\">This was a prospective cross-sectional study
of the descriptive type extending over a period of 6 months from July 01 to
December 31, 2021 on </span><span style=\"font-family:Verdana;\">all </span><span style=\"font-family:Verdana;\">children
with cancer followed in the pediatric hemato-oncology unit of the HND with a
renal, blood and urinary assessment associated with the GFR calculated by the
SCHWARTZ formula during the study period. </span><b><span style=\"font-family:Verdana;\">Results: </span></b><span style=\"font-family:Verdana;\">During the study
period, we registered 41 new cases of cancer in the pediatric oncology unit.
The age group of 0 - 5 years was the most represented, </span><i><span style=\"font-family:Verdana;\">i.e.</span></i><span style=\"font-family:Verdana;\"> 65.85% and the average age was 5.6 ¡À 4 years. The most cited
clinical signs were fever ie 56.10% followed by abdominal pain 34.15% and
anemia 26.83%. The most represented diagnosis was Burkitt¡¯s Lymphoma, </span><i><span style=\"font-family:Verdana;\">i.e.</span></i><span style=\"font-family:Verdana;\"> 26.83% followed by Retinoblastoma
24.39%. Mean serum creatinine was 70.65 ¡À 68.93 ¦Ìmol/L. In our series, patients
whose normal glomerular filtration rate were more represented, </span><i><span style=\"font-family:Verdana;\">i.e.</span></i><span style=\"font-family:Verdana;\"> 70.73% and 29.27% had an abnormal
GFR with an average of 87.28 ¡À 70 mL/min/1.73m</span><sup><span style=\"font-family:Verdana;\">2</span></sup><span style=\"font-family:Verdana;\">. Proteinuria and
leukocyturia were observed in 31.71% and 19.51% respectively. Glycosuria and
hematuria with common frequencies of 2.44% of patients. </span><b><span style=\"font-family:Verdana;\">Conclusion: </span></b><span style=\"font-family:Verdana;\">The
prevention of renal toxicity of anticancer drugs always involves the precise
evaluation of renal function using </span></span></span></span><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\"><span style=\"font-family:Verdana;\">the
Schwartz formula in
%K GFR
%K Child
%K Cancer
%K Chemotherapy
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=126636