%0 Journal Article
%T Association of Host Interferon-<i>¦Ã</i> Gene Polymorphism with <i>Toxoplasma gondii</i> Infection in Pregnant Women of Bangladesh
%A Nasrin Akter
%A Sonia Tamanna
%A Molie Rahman
%A Atiqur Rahman
%A Akm Mahbub Hasan
%A Taibur Rahman
%J American Journal of Molecular Biology
%P 156-169
%@ 2161-6663
%D 2023
%I Scientific Research Publishing
%R 10.4236/ajmb.2023.133011
%X Human toxoplasmosis is caused by
the intracellular protozoan parasite<i> Toxoplasma gondii. </i>Although <i>T.</i><i> gondii</i> infection is generally asymptomatic for most of the immunocompetent adults,
severe complications may occur particularly in pregnant women and
immunocompromised individual. Host cell immunity plays a critical role in
parasite differentiation and persistence in the host. Therefore, genetic
polymorphism in the host immune genes, for instance interferon-<i>¦Ã</i> gene could be linked with possibility
of <i>T.</i><i> gondii</i> infection. The objective of the study was to verify
the link between the single nucleotide polymorphisms (SNPs) in the IFN-<i>¦Ã</i> gene of pregnant women and <i>T.
gondii</i> infection through correlating with anthropometric and sociodemographic parameters. In this study, ninety-two (N =
92) pregnant women (16 - 40 years) and healthy controls (N = 95) with similar
age ranges were included. Among them, 25% (n = 23) pregnant women were
seropositive for <i>T. gondii </i>IgG
antibodies by Rapid Test Assay. Allelic and genotypic frequencies of IFN-<i>¦Ã</i> +874T/A (rs2430561) SNPs were
evaluated by using ARMS-PCR. The distribution
of the A and T alleles in the specific position of the IFN-<i>¦Ã</i> gene in the <i>T. gondii</i>-infected pregnant women and the
control groups did not differ significantly,
according to the data. However, we found a higher frequency (13.04%) of A/A genotype in <i>T. gondii</i> infected pregnant women as compared to
non-infected individuals (8.70%), demonstrating that <i>T. gondii</i> infection
susceptibility may be increased by homozygosity for the A allele. Further
studies are to be needed to find out the link between host gene polymorphism
and <i>T. gondii</i> infection in
Bangladesh.
%K &lt
%K i&gt
%K T. gondii&lt
%K /i&gt
%K Pregnant Women
%K Seroprevalence
%K IFN-&lt
%K i&gt
%K ¦Ã&lt
%K /i&gt
%K Gene
%K Polymorphism
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=126363