%0 Journal Article
%T 原发性痛风易感基因研究现状<br>Research Status of Susceptibility Genes of Primary Gout
%A 严鑫淼
%A 孙桃兰
%A 卢雨航
%A 谭馨
%A 李淼晶
%J Advances in Clinical Medicine
%P 11062-11069
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.1371543
%X 痛风是一种严重影响健康和生活质量的代谢性疾病，受到遗传因素和环境因素共同作用，且近年来患病率呈上升趋势。原发性痛风是一种多基因遗传性疾病，其发病及临床特征具有明显的遗传特异性。近年来，随着分子生物学技术的发展，全基因组关联分析(Genome-wide association studies, GWAS)已经检测到了导致痛风的多个易感位点和相关候选基因。本文简要介绍了这些基因以及其基因突变位点在痛风发病机制中的作用和对痛风发病的影响，以及这些基因与环境危险因素之间的潜在相互作用，以促进人们对痛风发病机制的理解。<br />
Gout is a metabolic disease that seriously affects health and quality of life. It is affected by both ge-netic and environmental factors, and its prevalence has been increasing in recent years. Primary gout is a polygenic genetic disease with significant genetic specificity in its pathogenesis and clinical characteristics. In recent years, with the development of molecular biology technology, ge-nome-wide association studies (GWAS) have detected multiple susceptibility sites and related can-didate genes that cause gout. This article briefly introduces the role of these genes and their muta-tion sites in the pathogenesis of gout and their impact on the pathogenesis of gout, as well as the potential interactions between these genes and environmental risk factors, in order to promote people’s understanding of the pathogenesis of gout.
%K 痛风，基因，全基因组关联分析<br>Gout
%K Gene
%K Genome-Wide Association Studies
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=68605