%0 Journal Article
%T 炎性细胞因子在糖尿病慢性创面中的作用机制研究进展<br>Research Progress on the Mechanism of Inflammatory Cytokines in Chronic Wounds of Diabetes
%A 姚步
%A 李毅
%J Advances in Clinical Medicine
%P 11006-11013
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.1371537
%X 糖尿病现已成为全球公认的严重公共卫生问题，临床表现为以高血糖为主要特征的代谢性疾病。长期高血糖导致心脑血管病变、肾脏病变、视网膜病变、周围神经血管病变、糖尿病足、糖尿病慢性创面等多种并发症，各类并发症中糖尿病慢性创面是最严重的并发症之一。炎性细胞因子是主要由免疫细胞生成的内源性多肽，可介导多种免疫反应。创面愈合期间由于炎症反应机体会产生大量炎性细胞因子，不同的细胞因子在炎症反应中发挥不同的生理作用，可表现为促进炎症进展或抑制炎症蔓延，细胞因子分泌的量决定创面愈合的时间周期。为了更加直观了解炎性细胞因子在糖尿病慢性创面中的作用机制，本文对炎性细胞因子在糖尿病慢性创面的相关作用机制作一综述，旨在为进一步研究提供新的观点。<br />
Diabetes is now recognized as a serious public health problem worldwide, with the clinical mani-festations of metabolic diseases characterized by hyperglycemia. Long-term hyperglycemia leads to cardiovascular and cerebrovascular lesions, renal lesions, retinopathy, peripheral neurovascular lesions, diabetic foot, diabetic chronic wounds and other complications, among which chronic dia-betic wounds are one of the most serious complications. Inflammatory cytokines are endogenous peptides produced primarily by immune cells that mediate a variety of immune responses. During wound healing, due to the inflammatory response, the body produces a large number of inflamma-tory cytokines, and different cytokines play different physiological roles in the inflammatory re-sponse, which can be manifested as promoting the progression of inflammation or inhibiting the spread of inflammation, and the amount of cytokine secretion determines the time cycle of wound healing. In order to better understand the mechanism of inflammatory cytokines in chronic wounds of diabetes, this article reviews the relevant mechanisms of inflammatory cytokines in chronic wounds of diabetes, aiming to provide new insights for further research.
%K 糖尿病，慢性创面，炎性细胞因子<br>Diabetes
%K Chronic Wounds
%K Inflammatory Cytokines
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=68532