%0 Journal Article
%T Nrf2信号通路在缺血性脑卒中的作用及研究进展<br>The Role and Research Progress of Nrf2 Signaling Pathway in Ischemic Stroke
%A 蒋雪野
%A 赵秀丽
%J Advances in Clinical Medicine
%P 10879-10885
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.1371519
%X 脑卒中患者中缺血性脑卒中占80%，具有高致残率及致死率，严重影响患者的生活质量，造成了严重的经济负担及社会负担。缺血性脑卒中是由于短时间内脑组织局部供血动脉血流减少或完全中断，导致缺血区域脑组织缺血、缺氧，造成不可逆的神经元损伤，损伤的程度取决于缺血的持续时间、严重程度和部位。研究显示，缺血性脑卒中的病理生理机制包括：局部脑血管低灌注、兴奋性神经毒性、氧化应激、血脑屏障破坏、微血管损伤、炎症反应、以及神经细胞和内皮细胞凋亡等一系列复杂的缺血级联反应。核因子E2相关因子2 (Nrf2)是内源性抗氧化防御的主要调节因子之一，在缺氧、氧化应激或炎症反应发生时，Nrf2与Keap1因子结合，调控大部分下游因子，发挥抗细胞凋亡、减轻炎症损伤、降低钙过载、抗氧化应激等多种作用，发挥维持线粒体稳态、保护脑组织损伤等作用。现就Nrf2信号通路在缺血性脑卒中的作用、研究进展及其激动剂在缺血性脑卒中的作用进行简要综述。<br />
Ischemic stroke accounts for 80% in stroke patients, which has a high rate of disability and fatality. Ischemic stroke seriously affects the quality of life of patients, and caused serious economic and so-cial burdens. Ischemic stroke was due to the reduction or complete interruption of the blood flow of the local blood supply arteries of the brain tissue in a short period of time, resulting in ischemia and hypoxia of the brain tissue in the ischemic area, which led to irreversible neuronal damage. The degree of damage depends on the duration of ischemia, severity and location. Studies had shown that the pathophysiological mechanisms of ischemic stroke include: regional cerebral vascular hy-poperfusion, excitotoxicity, oxidative stress, blood-brain barrier dysfunction, microvascular injury, inflammatory response, and apoptosis of nerve cells and endothelial cells. Nuclear factor E2-related factor 2 (Nrf2) was one of the main regulators of endogenous antioxidant defense. When hypoxia, oxidative stress or inflammatory response occurs, Nrf2 combines with Keap1 factor to regulate downstream factors and play an anti-oxidative role. Nrf2 signaling pathway played a role of an-ti-apoptosis, reducing inflammatory damage, reducing calcium overload, anti-oxidative stress and other functions, maintaining mitochondrial homeostasis and protecting brain tissue. This article reviews the role of Nrf2 signaling pathway in ischemic stroke, research progress and Nrf2 agonists in ischemic stroke.
%K 缺血性脑卒中，Keap1/Nrf2，氧化应激，炎症反应<br>Ischemic Stroke
%K Keap1/Nrf2
%K Oxidative Stress
%K Inflammation
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=68429