%0 Journal Article
%T Urachal Cancer: Experience of a High-Volume Bladder Cancer Center
%A Abdulla Uthman
%A Christopher C. Khoo
%A Jiten Jaipuria
%A Ahmed Abdel-Aziz
%A Nathan Taylor
%A Norma Gibbons
%A David Hrouda
%A Giles Hellawell
%A Eva Bolton
%J Open Journal of Urology
%P 201-213
%@ 2160-5629
%D 2023
%I Scientific Research Publishing
%R 10.4236/oju.2023.137025
%X <strong>Introduction:</strong> Primary urachal cancer (UrCa) is rare, with an estimated incidence of 0.2% - 0.5% of all bladder tumors. Although the preferred treatment is surgical, there is no consensus on the best approach. We present our experience managing 14 cases of primary UrCa. <strong>Methods:</strong> A retrospective analysis was conducted on the clinical records of a high-volume bladder cancer center in the UK to identify patients diagnosed with UrCa between May 2013 and June 2022. <strong>Results:</strong> 9 males and 6 females, aged between 30 and 85 years, were included. The diagnosis was most commonly made via flexible cystoscopy and CT for haematuria. 3 patients had metastasis at presentation, and while radiologically no patients showed positive lymph nodes, 2 patients were found to have positive lymph nodes on histopathology. 13 patients underwent partial cystectomy, with 1 undergoing radical cystoprostatectomy. 8 patients underwent concurrent umbilectomy and/or lymphadenectomy. The most common histological subtype was mucinous adenocarcinoma. 2 patients experienced local recurrence and underwent transurethral resection, while 6 patients experienced metastasis. Metastasis-free survival rate was 74.1% and 55.6% at 12 and 24 months, respectively. Umbilectomy and lymphadenectomy did not decrease rates of positive surgical margin, local recurrence, metastasis, or mortality. <strong>Conclusions:</strong> UrCa is a rare and aggressive malignancy that can occur at any age and may be advanced upon presentation. Bladder-sparing surgery is becoming more prevalent, with chemotherapy being reserved for recurrence or metastasis. In our series, routine umbilectomy and lymphadenectomy did not improve oncologic outcomes. However, lymphadenectomy may have a role in cancer staging.
%K Urachal Cancer
%K Urachus
%K Bladder Cancer
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=126148