%0 Journal Article
%T Evaluation of Immunological Markers in Children Infected with Intestinal Parasites in Three Communities, Nigeria
%A Eze Chinwe Nwadiuto
%A Jonah S. Aprioku
%J Open Journal of Immunology
%P 45-59
%@ 2162-4526
%D 2023
%I Scientific Research Publishing
%R 10.4236/oji.2023.132004
%X Helminthiases are neglected parasites that induce changes in <span><span><span style=\"font-family:;\" \"=\"\">the </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">host</span></span></span><span><span><span style=\"font-family:;\" \"=\"\">¡¯s</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> immune response. The study assayed some immunological markers in helminth
infections in children and adolescents. Stool and blood samples were collected
from 276 subjects resident in three rural communities of Rivers and Imo States.
Of these, 98 (35.5%) were infected with one or more of 3 parasitic species, of
which <i>Ascaris lumbricoides</i> 39</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">(39.8%), <i>Ancylostoma duodenale</i> 30</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">(30.6%)<i> </i>and <i>Trichuris
trichiura </i>29</span></span></span><span><span><i><span style=\"font-family:;\" \"=\"\"> </span></i></span></span><span><span><span style=\"font-family:;\" \"=\"\">(29.6%) were recovered. Intestinal helminth parasites were identified
using formol</span></span></span><span><span><span style=\"font-family:;\" \"=\"\">-</span></span></span><span><span><span style=\"font-family:;\" \"=\"\">ether concentration. Of the infected subjects, 66 had single species
infections and 32 had multiple infections with two or three helminth species
and children of </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">the </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">6</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">-</span></span></span><span><span><span style=\"font-family:;\" \"=\"\"> </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">10 years age group had the highest incidence. Sera of 60 infected
subjects and 30 controls were evaluated to define immunological serum levels of
IgE, IL-5, IFN-<i>¦Ã</i> and C3 using </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">the </span></span></span><span><span><span style=\"font-family:;\" \"=\"\">ELISA technique, while white blood cell differential counts and
neutrophil-lymphocyte ratio (NLR) were evaluated using haematology
auto-analyser. Elevation of IL-5, IgE, WBC and eosinophil levels were
demonstrated in the infected groups (p
%K Immune Response
%K Parasites
%K Helminth
%K Neutrophil
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=126134