%0 Journal Article
%T Confocal Laser Endomicroscopy in the Field of Esophageal Diseases
%A Peiting Xue
%A Xiuli Zuo
%J Advances in Bioscience and Biotechnology
%P 279-297
%@ 2156-8502
%D 2023
%I Scientific Research Publishing
%R 10.4236/abb.2023.146017
%X Confocal laser endomicroscopy (CLE) is a new endoscopic imaging
technology that allows real-time, high-resolution observation of tomographic
images <span>of mucosal cells and subcellular
levels <i>in vivo</i>, detecting microscopic
structural </span>changes in mucosal morphology, and its <i>in vivo</i> immediate pathological di<span>agnostic
capability can avoid delays in mucosal pathological diagnosis and reduce</span> the pain caused by repeated biopsies. CLE is known as </span><span style=\"font-family:&quot;\">¡°</span><span style=\"font-family:&quot;\">optical biopsy</span><span style=\"font-family:&quot;\">¡±</span><span style=\"font-family:&quot;\"> and
compared with other endoscopic techniques,</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\">it has
obvious advantages.</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\">CLE
systems include probe-based confocal laser endomicroscopy (pCLE) and
endoscope-based confocal laser endomicroscopy (eCLE).</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\">Since 2006, CLE has been widely used for the
evaluation of various lesions in the digestive system, including</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\">esophageal, gastric, and colonic neoplasia,
pancreatic cysts and solid lesions, and inflammatory bowel disease. The advent
of CLE has made <i>in vivo</i> microscopic
imaging</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\">possible, which has changed</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\">the endoscopic screening and diagnosis of multiple
gastrointestinal (GI) lesions.</span><span style=\"font-family:&quot;\"> </span><span style=\"font-family:&quot;\">However,
the value of its use in GI diseases is still controversial. In this review, we
focus on the application of CLE in the field of esophageal diseases.
%K Confocal Laser Endomicroscopy (CLE)
%K Barrett¡¯s Esophagus (BE)
%K High-Grade Dysplasia (HGD)
%K Esophagus Cancer (EC)
%K Gastroesophageal Reflux Disease (GERD)
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=125876