%0 Journal Article
%T Prevalence and Resistance Profile of Muenchen Cefotaximase (CTX-M) Group 1 Extended Spectrum Beta-Lactamase (ESBL)-Producing Uropathogenic <i>Escherichia coli</i> Strains  in Dakar, Senegal
%A Abdoulaye Seck
%A Babacar Ndiaye
%A Abdou Diop
%A Malick Ndao
%A Cheikh Fall
%A Assane Dieng
%A Thierno Abdoulaye Diallo
%A Chantal Mahou
%A Philippe Dubrous
%J Open Journal of Medical Microbiology
%P 137-145
%@ 2165-3380
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojmm.2023.132012
%X <b><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">Background: </span></b><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">Extended-spectrum beta-lactamase
(ESBL) producing bacteria are a real public health problem, particularly in Africa.
Among these ESBLs, there are the Muenchen Cefotaximase (CTX-M) described all over
the world <span>of which the most frequent is the CTX-M
of group 1 particularly the CTX-M-15</span> <span>variant.
The objective of this study was to determine the prevalence of CTX-M</span> group
1 ESBL-producing <i>Escherichia coli</i> strains and to test their antibiotics susceptibility
profile. <b>Methodology:</b> A retrospective cross-sectional descriptive study was
conducted to detect ESBL-secreting <i>Escherichia
coli</i> strains by the synergy test. Identification of CTX-M type ESBL from group
1 was performed using the NG-Test CTX-M rapid diagnostic test (NG-Biotech<span style=\"font-family:Verdana, Helvetica, Arial;text-wrap:wrap;background-color:#FFFFFF;\">&amp;#174;</span>). Antibiotic
susceptibility profile was determined using CA-SFM/EUCAST guidelines 2019. Data
entry and statistical analysis were performed with Excel version 2010 and SPSS 20.0
respectively. <b>Results: </b>Eighty-two ESBL-producing <i>Escherichia coli</i> strains were tested. A group 1 CTX-M ESBL was detected in 75.6% of the strains (n</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> </span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">=</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> </span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">62). These strains were highly resistant to cefotaxim (100%), aztreonam (100%),
ceftazidim (85.4%) and cefepim (66.1%). They were also resistant to quinolones,
gentamycin and sulfadoxine-trimethoprim combination. However, these strains showed
sensitivity to ertapenem (100%), cefoxitin (69.3%), tigecyclin (66%), and amikacin
(66.1%). The combination of piperacillin and tazobactam was active on 30.6% of the
strains against 6.4% for the combination of amoxicillin and clavulanic acid. <b>Conclusion: </b>The CTX-M type ESBL of group 1 was present in the majority of ESBL-producing <i>Escherichia coli</i>s</span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\"> </span><span style=\"font-size:10.0pt;font-family:;\" \"=\"\">trains. Despite the production
of this enzyme conferring resistance to most beta-lactam antibiotics, some antibiotics
remain active to treat infections caused by these germs.</span>
%K &lt
%K i&gt
%K Escherichia coli&lt
%K /i&gt
%K ESBL
%K CTX-M Group
%K Prevalence
%K Antibiotic Resistance
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=125693