%0 Journal Article
%T 缺氧骨髓微环境与急性髓系白血病的相关研究<br>Study of Hypoxic Bone Marrow Microenvironment Associated with Acute Myeloid Leukemia
%A 王爱博
%A 李文倩
%J Advances in Clinical Medicine
%P 9163-9169
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.1361283
%X 急性白血病中最常见的类型是急性髓系白血病，约占成人病例的80%，且生存率很低。急性髓系白血病是一种侵袭性的血液系统恶性肿瘤，而缺氧是肿瘤的常见现象。近年来，众多研究发现缺氧骨髓微环境在急性髓系白血病发病机制中发挥重要作用。因此，有必要对缺氧骨髓微环境与急性髓系白血病的能量代谢、血管生成、调控细胞增殖、促进细胞归巢、耐药等方面的关系进行阐述。<br />
The most common type of acute leukemia is acute myeloid leukemia, which accounts for approxi-mately 80% of adult cases and has a poor survival rate. Acute myeloid leukemia is a highly hetero-geneous hematologic neoplasm. Hypoxia is a common phenomenon in neoplasms. In recent years, numerous studies have found that the hypoxic bone marrow microenvironment plays an important role in the pathogenesis of acute myeloid leukemia. Therefore, it is necessary to elaborate the rela-tionship between the hypoxic bone marrow microenvironment and acute myeloid leukemia in terms of energy metabolism, angiogenesis, regulation of cell proliferation, promotion of cell homing, and drug resistance.
%K 缺氧骨髓微环境，急性髓系白血病，HIF-1α，发病机制<br>Hypoxic Bone Marrow Microenvironment
%K Acute Myeloid Leukemia
%K HIF-1α
%K Pathogenesis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=66885