%0 Journal Article
%T Early Morbidity and Mortality in Neonates of Mothers with Sickle Cell Disease at the Borgou/Alibori Center Departmental Teaching Hospital in Benin
%A Alphonse Noudamadjo
%A Falilatou Agbeille Mohamed
%A M¨¦d¨¦tinm¨¨ Kpanidja G¨¦rard
%A Mahublo Voduhe
%A Justin Chogou
%A Guedenon Romulus
%A Julien Didier Adedemy
%A Joseph Agossou
%J Open Journal of Pediatrics
%P 437-449
%@ 2160-8776
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojped.2023.133049
%X <strong>Introduction</strong><span><span><span style=\"font-family:&quot;\"><strong>:</strong> Association of sickle cell disease and pregnancy is a risky situation
for both the mother and neonate. <b>Objective</b>: To determine the early
morbidity and mortality among neonates of mothers with sickle cell disease at
Borgou/Alibori Center Departmental Teaching Hospital (CHUD B/A) in Benin. <b>Patients
and Methods</b>: This was a descriptive and analytical observational study
conducted at CHUD-B/A from January 1, 2015, to August 31, 2019. It included
pregnant women with sickle cell disease who gave birth to a liveborn neonate at
the term of at least 28 weeks of amenorrhea. Variables <span>studied were sociodemographic, clinical, and evolutionary. Analysis of
the factors associated with early death was also carried out with a
significance </span>threshold set at p &lt; 0.05. <b>Results</b>: Out of a
total of 119 pregnant women, 95 neonates were recorded. Main morbidities were:
prematurity and intrauterine <span>growth
restriction (49.5%); respiratory distress (40%), bacterial infectio</span>n
(30.5%), and perinatal asphyxia (21.1%). Early mortality rate was 8.4%.</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span><span><span style=\"font-family:&quot;\">In
bivariate analysis, the factors associated with early death were: parity (p
&lt; 0.001), the severity of maternal anemia (p &lt; 0.008), birth weight under
1500</span></span></span><span><span><span style=\"font-family:&quot;\"> </span></span></span><span><span><span style=\"font-family:&quot;\">g (p &lt; 0.002), the birth term under 32 weeks of amenorrhea (p &lt;
0.001), resuscitation for at least 5 minutes (p = 0.001). In multivariate
analysis, resuscitation for at least 5 minutes (p = 0.007) was mainly
associated with early death. <b>Conclusion</b>: One out of two neonates of
mothers with sickle cell disease has a low birth weight. Early mortality is
high due to perinatal asphyxia. Hence the multidisciplinary care of these
mothers.</span></span></span>
%K Early
%K Morbidity
%K Mortality
%K Neonates
%K Mothers
%K Sickle Cell Disease
%K Benin
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=125237