%0 Journal Article
%T Plasma Levels of Transforming Growth Factor-Beta 1 in Women with Pelvic Organ Prolapse
%A Kimio Sugaya
%A Katsumi Kadekawa
%A Katsuhiro Ashitomi
%A Saori Nishijima
%A Seiji Matsumoto
%J Open Journal of Urology
%P 133-142
%@ 2160-5629
%D 2023
%I Scientific Research Publishing
%R 10.4236/oju.2023.135017
%X <strong>Objective:</strong> In women with pelvic organ prolapse (POP), decreased expression of transforming growth factor-beta 1 (TGF-<i>¦Â</i>1) has been shown in POP tissues. However, no studies have evaluated plasma TGF-<i>¦Â</i>1 levels in patients with POP, so it is unknown whether they are also changed or not. Therefore, we compared plasma TGF-<i>¦Â</i>1 levels in women with and without POP. <strong>Methods:</strong> Participants were 49 women with POP and 23 healthy control women. All participants were postmenopausal. We measured plasma TGF-<i>¦Â</i>1 and compared data between patients with POP and controls, and between patients with uterine prolapse (UP, n = 19) and those with a cystocele (CC, n = 30). In addition, in patients, we assessed the POP quantification system (POP-Q) stage. <strong>Results:</strong> Plasma TGF-<i>¦Â</i>1 levels were significantly lower in patients than in healthy controls. POP-Q stage was not significantly different between the UP and CC subgroups, but POP-Q stage IV was diagnosed in 63% of patients with UP and 7% of those with CC. Plasma TGF-<i>¦Â</i>1 levels were significantly lower in the CC subgroup than in the UP subgroup. <strong>Conclusion:</strong> Plasma TGF-<i>¦Â</i>1 is decreased in POP. It remains unclear whether the lower levels indicate a reduction in systemic TGF-<i>¦Â</i>1 activity, but they can be assumed to reflect reduced TGF-<i>¦Â</i>1 expression in POP tissues.
%K Cystocele
%K Pelvic Organ Prolapse
%K Transforming Growth Factor-Beta 1 (TGF-&lt
%K i&gt
%K ¦Â&lt
%K /i&gt
%K 1)
%K Uterine Prolapse
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=125041