%0 Journal Article
%T MMP11基因对肺腺癌诊断和预后的影响<br>Effect of MMP11 Gene on Diagnosis and Prognosis of Lung Adenocarcinoma
%A 赵强
%A 李兴广
%J World Journal of Cancer Research
%P 69-78
%@ 2164-9057
%D 2023
%I Hans Publishing
%R 10.12677/WJCR.2023.132011
%X 目的：分析MMP11基因在肺腺癌中的表达特征，并评估其对肺腺癌诊断和预后的影响。方法：从TCGA数据库中下载肺腺癌转录组数据，利用生物信息学方法对MMP11在肺腺癌中的表达特征进行分析、并将该基因的表达特征与临床信息进行关联分析，进而对肺腺癌诊断及预后的影响进行系统分析。结果：MMP11基因在肺癌中高表达，对肺腺癌的诊断具有重要价值，但对肺腺癌预后的影响还有待于进一步研究。结论：MMP11基因有可能成为肺腺癌诊断相关的重要生物标记物。<br />
Objective: To analyze the characteristics of MMP11 expression in lung adenocarcinoma and evaluate the impact on diagnosis and prognosis of lung adenocarcinoma. Method: The transcriptomic data of lung adenocarcinoma were downloaded from the TCGA database, and the expression characteristics of MMP11 in lung adenocarcinoma were analyzed by bioinformatic method, and then the expression characteristics of MMP11 were correlated with clinical information, so as to systematically analyze its influence on lung adenocarcinoma’ diagnosis and prognosis. Result: MMP11 gene is highly expressed in lung cancer and plays a significant role in the diagnosis of lung adenocarcinoma, but its effect on the prognosis of lung adenocarcinoma remains to be further elucidated. Conclusion: MMP11 gene may be an important biomarker in the diagnosis of lung adenocarcinoma.
%K MMP11，肺腺癌，诊断，预后<br>MMP11
%K Lung Adenocarcinoma
%K Diagnosis
%K Prognosis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=64483