%0 Journal Article
%T 白细胞介素-17在相关皮肤病中的研究进展<br>Research Progress of Interleukin-17 in Related Skin Diseases
%A 何酉丰
%A 王宝庭
%J Advances in Clinical Medicine
%P 5229-5235
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.134740
%X 白细胞介素-17 (IL-17)是一种必不可少的促炎细胞因子，主要由CD4+辅助T细胞(Th17细胞)和先天淋巴样细胞亚群分泌。IL-17与多种炎症性疾病的发病机制有关，包括银屑病、化脓性汗腺炎、毛发红糠疹、特应性皮炎、斑秃和系统性硬化症。目前已经证实IL-23/IL-17轴是炎症性疾病的靶向治疗的重要途径。来自临床试验的新证据表明，针对IL-17的单克隆抗体对治疗银屑病、化脓性汗腺炎、毛发红糠疹和系统性硬化症患者是有效的。<br />
Interleukin-17 (IL-17), an essential pro-inflammatory cytokine, is largely released by CD4+ helper T cells (Th17 cells) and a subset of innate lymphoid cells. IL-17 has been linked to the pathogenesis of various inflammatory diseases, including psoriasis, hidradenitis suppurativa, pityriasis rubra pi-laris, atopic dermatitis, alopecia areata and systemic sclerosis. Recently, it has been demonstrated that the IL-23/IL-17 axis is a crucial approach for targeted treatments of inflammatory diseases. According to new evidence from clinical trials, monoclonal antibodies against IL-17 may be helpful in treating patients with psoriasis, hidradenitis suppurativa, pityriasis rubra pilaris and systemic sclerosis.
%K 皮肤病，白细胞介素-17<br>Dermatopathya
%K Interleukin-17
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=63716