%0 Journal Article
%T 大鼠肾衰竭模型造模方法研究进展<br>Comparative Research Progress on Modeling Methods of Rat Renal Failure Models
%A 娜芭尔·吐尔逊艾力
%A 刘珍
%J Advances in Clinical Medicine
%P 3613-3620
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.133517
%X 基于动物疾病模型，进一步探究人类疾病模型，是深入研究疾病发生机制以及药物临床作用的重要手段。肾衰动物模型研究已开展，但对于模型之间的比较研究却较少。本文以大鼠肾衰竭模型为切入点，分别从制作方法，模型评价和科研应用的角度，对大鼠慢性肾衰竭(CRF)病理模型和急性肾衰竭(ARF)病理模型进行了分析和对比，期望能为临床上肾衰发病机制的研究、肾衰治疗药物的研发、动物实验模型的准确选取和构建提供一定的参考。<br />
The exploration of human disease using animal disease models is an important means to study the mechanisms underlying disease occurrence and the clinical effects of drugs. At present, various animal models of renal failure have been developed, but there are few comparative studies of such models. This article takes the rat renal failure model as the starting point, the pathological models of chronic renal failure (CRF) and acute renal failure (ARF) in rats were analyzed and compared from the perspectives of production methods, model evaluation and scientific research application, hoping to provide some reference for the clinical study of the pathogenesis of renal failure, the re-search and development of therapeutic drugs for renal failure, and the accurate selection and con-struction of animal experimental models.
%K 大鼠，肾衰模型<br>Rat
%K Renal Failure Model
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=62504