%0 Journal Article
%T 血小板衍生生长因子及受体在肥胖和糖尿病中的研究进展<br>Research Progress of Platelet-Derived Growth Factor and Its Receptor in Obesity and Diabetes
%A 王延淼
%A 信立霞
%A 张玉荣
%A 刘洋
%A 刘元涛
%J Advances in Clinical Medicine
%P 3117-3124
%@ 2161-8720
%D 2023
%I Hans Publishing
%R 10.12677/ACM.2023.133443
%X 近年来肥胖和糖尿病的患病率逐年增加，严重影响人们的生活质量。随着科研的不断进展，这类疾病的相关分子及信号通路的研究成为热门。血小板衍生生长因子(platelet-derived growth factor, PDGF)作为一种促血管生成因子，成员有PDGF-AA，PDGF-BB，PDGF-CC，PDGF-DD，PDGF-AB五种类型，其受体(platelet-derived growth factor receptor, PDGFR)属于酪氨酸蛋白激酶受体家族，它们不仅参与血管再生和创伤修复等重要生理过程，还在肿瘤细胞增殖、迁移及器官组织纤维化方面发挥重要作用，PDGF/PDGFR已成为基础生物学与转化医学研究所关注的重要靶点。近年研究发现，PDGF配体及受体与脂肪组织扩增及糖代谢关系密切。本文总结了目前已知关于PDGF及受体的结构与功能，并对其在肥胖及糖尿病方面的研究进行了梳理，以期望其能为肥胖和糖尿病的研究和治疗提供新方向。<br />
In recent years, the prevalence of obesity and diabetes is increasing gradually, which seriously af-fects the quality of people’s life severely. With the advance of scientific research, the related mole-cules and signaling pathways of these diseases have become a hot topic. Platelet-derived growth factor (PDGF), as an angiogenic cytokines, consists of five molecular structures including PDGF-AA, PDGF-BB, PDGF-CC, PDGF-DD and PDGF-AB. Platelet-derived growth factor receptor (PDGFR) belongs to the tyrosine protein kinase receptor family. Platelet-derived growth factor receptor is not only involved in important physiological processes such as angiogenesis and wound repair, but also plays an important role in tumor cell proliferation, migration and organ tissue fibrosis. PDGF/PDGFR has become an important target in the research of basic biology and translational medicine. In recent years, it has been found that PDGFs and their receptors are closely related to adipose expansion and glucose metabolism. In this paper, the structure and function of PDGF and its receptors were summarized, and the research on its role in obesity and diabetes was reviewed in order to provide a new direction for the research and treatment of obesity and diabetes.
%K 血小板衍生生长因子，受体，肥胖，糖尿病<br>PDGF
%K Receptor
%K Obesity
%K Diabetes
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=62257