%0 Journal Article
%T Cannabidiol-Mediated Sequestration of Alzheimer¡¯s Amyloid-<i>¦Â</i> Peptides in ADDL Oligomers
%A Yang Li
%A Fengyuan Zhang
%A Caroline E. Herron
%A Ivonne Rosales
%A Alejandro Heredia
%A Nicolae-Viorel Buchete
%A Brian J. Rodriguez
%J American Journal of Molecular Biology
%P 113-126
%@ 2161-6663
%D 2023
%I Scientific Research Publishing
%R 10.4236/ajmb.2023.132008
%X Cannabidiol (CBD), one of the most studied phytocannabinoids, is non-psychotropic and can induce protective effects on the central nervous system against acute and chronic brain injury. Interestingly, CBD inhibits processes relating to amyloid beta (A<em>¦Â</em>)-induced neurotoxicity in mouse models of Alzheimer¡¯s disease, though the detailed molecular mechanism underlying the CBD neurotoxicity modulation is not fully understood. In this study, using atomic force microscopy, we find that CBD promotes the aggregation of A<em>¦Â</em> peptides, enhancing the formation of A<em>¦Â</em> oligomers, also known as A<em>¦Â</em>-derived diffusible ligands (ADDLs). The CBD-mediated sequestration of A<em>¦Â</em> monomers in soluble ADDLs could reduce neurotoxicity. This study highlights a possible role of CBD in modulating the formation of ADDL aggregates and provides insight into potentially neuroprotective properties of CBD in Alzheimer¡¯s disease.
%K Cannabidiol
%K Amyloid
%K Alzheimer¡¯s Amyloid-&lt
%K i&gt
%K ¦Â&lt
%K /i&gt
%K Peptides
%K A&lt
%K i&gt
%K ¦Â&lt
%K /i&gt
%K -Derived Diffusible Ligands
%K Atomic Force Microscopy
%K Amyloid Peptide Sequestration
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=123502