%0 Journal Article
%T 补肾活血法治疗卵巢型子宫内膜异位囊肿的有效性和安全性的Meta分析<br>Efficacy and Safety of Bushen Huoxue in the Treatment of Ovarian Endometrioma: A Systematic Review and Meta-Analysis
%A 赵璐嘉
%A 马静
%J Traditional Chinese Medicine
%P 141-150
%@ 2166-6059
%D 2023
%I Hans Publishing
%R 10.12677/TCM.2023.121024
%X 目的：运用Meta分析评价补肾活血法治疗卵巢型子宫内膜异位囊肿的临床疗效。方法：计算机检索自建库至2022年6月的CNKI、VIP、WanFang、CBM、Web of Science、PubMed、Cochrane Library等数据库。收集采用补肾活血法治疗卵巢型子宫内膜异位囊肿的临床随机对照试验，由2名研究者各自进行文献筛选、数据提取、文献偏倚风险评估后，采用RevMan5.3软件完成Meta分析。结果：共纳入12项研究，1063例卵巢型子宫内膜异位囊肿患者。Meta分析结果显示：运用补肾活血法治疗卵巢型子宫内膜异位囊肿的治疗组在提高总有效率[RR = 1.15, P &lt; 0.00001, 95%CI = (1.09, 1.20)]、缩小异位囊肿大小[MD = ？1.22, 95%CI(？3.10, ？0.66)]、降低复发率[RR = 0.16, P = 0.0001, 95%CI = (0.07, 0.41)]、减少不良反应[RR = 0.25, P = 0.01, 95%CI = (0.09, 0.74)]、改善痛经症状[MD = ？0.38, 95%CI(？0.51, ？0.25)]方面均优于对照组。根据干预时间对血清CA<sub>125</sub>值进行亚组分析，干预时间 &gt; 3个月血清CA125值为[MD = ？5.16, 95%CI (？6.45, ？3.87)]，干预时间 ≤ 3个月为[MD = ？3.40, 95%CI(？4.08, ？2.72)]。结论：中医补肾活血法能够更有效地缓解卵巢型子宫内膜异位囊肿患者的临床症状，缩小异位囊肿大小，减少复发率，降低不良事件的发生。<br />
Objective: To analyze the clinical efficacy of Bushen Huoxue in the treatment of ovarian endome-trioma by Meta-analysis. Methods: Literatures were searched through CNKI, VIP, WanFang, CBM, Web of Science, PubMed, Cochrane Library and other databases from the establishment of the database to June 2022. To collect the clinical randomized controlled trials of Bushen Huoxue in the treatment of ovarian endometrioma, then two researchers independently screened the literature, extracted information and assessed the risk of literature bias. Finally, RevMan5.3 software was used to complete the meta-analysis. Results: A total of 12 studies involving 1063 patients with ovarian endometrioma were included. The results of meta-analysis showed that: The total clinical effective rate of Bushen Huoxue recipe in the treatment of ovarian endometrioma is [RR = 1.15, P &lt; 0.00001, 95%CI = (1.09, 1.20)]. The size of ectopic cyst, recurrence rate, adverse reaction rate and dysmenorrhea symptom score were as follows: [MD = ？1.22, 95%CI(？3.10, ？0.66)], [RR = 0.16, P = 0.0001, 95%CI = (0.07, 0.41)], [RR = 0.25, P = 0.01, 95%CI = (0.09, 0.74)], [MD = ？0.38, 95%CI(？0.51, ？0.25)]. Subgroup analysis was performed on serum CA<sub>125</sub> values according to different intervention time, intervention time &gt; 3 months [MD = ？5.16, 95%CI(？6.45, ？3.87)], intervention time ≤ 3 [MD = ？3.40, 95%CI(？4.08, ？2.72)]. Conclusion: Traditional Chinese medicine method of Bushen Huoxue has the advantage of high safety, certain effect. It can more effectively relieve the clinical symptoms of patients with ovarian endometrioma, reduce the size of ectopic cyst.
%K 补肾活血法，随机对照试验，卵巢型子宫内膜异位囊肿，Meta分析<br>Bushen Huoxue
%K RCT
%K Ovarian Endometrioma
%K Meta-Analysis
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=60349