%0 Journal Article
%T Association of Vitamin D Deficiency with Diabetic Retinopathy in Young People with Type 1 Diabetes Mellitus
%A Abir Bin Sajj
%A Bedowra Zabeen
%A Mohammad Zafar Khaled
%A Nuzhat Choudhury
%A Tohura Sharmin
%J Open Journal of Ophthalmology
%P 48-63
%@ 2165-7416
%D 2023
%I Scientific Research Publishing
%R 10.4236/ojoph.2023.131006
%X <strong>Background:</strong> Diabetic retinopathy is among the most common diabetic complications, and is one of the leading causes of blindness in the world. Recent studies have linked vitamin D to the pathogenesis of diabetes and there is growing evidence that vitamin D can interfere with the mechanisms involved in diabetes and its complications. Despite improvements in treatment, diabetic retinopathy remains a significant complication of type 1 diabetes mellitus. Identification of early treatable predictors of diabetic retinopathy such as vitamin D deficiency, may allow more aggressive management of those at high risk. <strong>Purpose:</strong> To assess the association of vitamin D deficiency with diabetic retinopathy in young people with type 1 diabetes mellitus. <strong>Design: </strong>Observational study with case control design. <strong>Method:</strong> 60 young people with type 1 diabetes aged between 11 to 24 years were included in this study. Among them, 30-young people have diabetic retinopathy and 30-young people do not have diabetic retinopathy. Purposive sampling technique was applied as per inclusion criteria. Statistical analysis of the results was done by using computer-based software, SPSS version 26. P value of less than 0.05 was considered as statistically significant. <strong>Results:</strong> Vitamin D deficiency was present in 83% of the young people with diabetic retinopathy and in 53% without diabetic retinopathy. The mean vitamin D level in young people with and without diabetic retinopathy was 17.38 ¡À 3.77 ng/ml and 20.15 ¡À 5.06 ng/ml respectively and the difference was statistically significant (p = 0.019). Vitamin D deficiency was increased with the severity of diabetic retinopathy. Univariate and multivariate logistic regression showed vitamin D deficiency was independently associated with diabetic retinopathy with a crude odds ratio of 5.69 with a p value of 0.008 and adjusted odds ratio of 16.08 with a p value of 0.002 respectively. <strong>Conclusion:</strong> Result of the study revealed that vitamin D deficiency was strongly associated with diabetic retinopathy in young people with type 1 diabetes mellitus.
%K Vitamin D Deficiency
%K Type 1 Diabetes Mellitus
%K Diabetic Retinopathy
%K Young People
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=122963