%0 Journal Article
%T Synthesis and Antitumor Activity of 3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[<i>d</i>] Isoxazole-4,6-Diol
%A Li Wang
%J International Journal of Organic Chemistry
%P 1-6
%@ 2161-4695
%D 2023
%I Scientific Research Publishing
%R 10.4236/ijoc.2023.131001
%X A new phloretin derivative 1 3-[2-(4-hydroxy-phenyl)-ethyl]-benzo[d] isoxazole-4,6-diol (yield 63%) was synthesized from phloretin by carbonyl nucleophilic addition condensation reaction. Its structure was characterized by 1H NMR, 13C NMR and HR-MS. The phloretin, compound 1, resveratrol and acetylated resveratrol were determined by comparing them with paclitaxel. Anti-tumor activity of alcohol on SPC-A1, EC109, A549, MCF-7 and MDA-MB-231 cell lines. Compound 1 showed better antitumor activity than docetaxel against A549 tumor cells.
%K 3-[2-(4-Hydroxy-Phenyl)-Ethyl]-Benzo[&lt
%K i&gt
%K d&lt
%K /i&gt
%K ] Isoxazole-4
%K 6-Diol
%K Synthesis
%K Antitumor Activity
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=122846