%0 Journal Article
%T The <i>in Vitro</i> Characterisation of the Effect of Selexipag on Small Human Pulmonary Arteries
%A Salman Arif
%A Mohamed Abdi
%A Bilal Qaddoura
%A Ghazi Elshafi
%A Syed Qadri
%A Mubarak Chaudhry
%A Mahmoud Loubani
%A Azar Hussain
%J World Journal of Cardiovascular Surgery
%P 293-303
%@ 2164-3210
%D 2022
%I Scientific Research Publishing
%R 10.4236/wjcs.2022.1212026
%X Objective: There is a lack of data on the direct effects of
Selexipag, a novel prostacyclin Inositol phosphate-3 receptor (IP3) agonist
with a long half-life, on human pulmonary arteries. This study aims to
establish the efficacy and potency of Selexipag on human pulmonary arteries. Methods: Patient consent was obtained prior to lung
resection for primary lung cancer. The pulmonary artery rings (n = 23 from 6
patients) were cut to 2 - 4 mm length and 2 - 4 mm internal diameter. They
were mounted on a wire myograph under physiological
conditions and were pre-constricted to prostaglandin F2¦Á. Concentration response curves were constructed to
Selexipag by cumulative addition to the myograph chambers. The viability of the
rings was confirmed with Acetylcholine and potassium chloride. Results: The Selexipag caused dose dependent vasodilation to
human pulmonary arteries. The range of doses used was from 1 pM to 30 uM, n = 4 were excluded
due to non-reactivity and n = 19 were included. Initial significant
vasodilation of PAs was noted at 3 uM. Maximal response was achieved at 10