%0 Journal Article
%T Use of the D614G Mutation of the SARS-CoV-2 Spike Protein as a Biophysical Model to Explain Coulomb¡¯s Law Function
%A Michelle Fuentes-Acosta
%A Jorge Mulia-Rodr¨ªguez
%A Daniel Osorio-Gonz¨¢lez
%J Creative Education
%P 103-110
%@ 2151-4771
%D 2023
%I Scientific Research Publishing
%R 10.4236/ce.2023.141008
%X The scientific work of Charles-Augustin de Coulomb has transcended as a significant contribution to explain phenomena in nature and generate crucial technological development in recent daily activities. We used Coulomb¡¯s law to calculate the changes generated in the electrostatic interactions of residue 614 of SARS-CoV-2 Spike protein when the D614G mutation occurs. We made a physical analysis of the transformation and the biological implications in the whole molecule¡¯s structural stability, obtaining that a greater electronegativity of the mutation stage favors the open state of Spike, which is manifested as a greater efficiency to bind to the ACE2 human receptor.
%K Spike
%K Coulomb¡¯s Law
%K Electrostatic Interactions
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=122623