%0 Journal Article %T Tumor Necrosis Factor-Alpha (TNF)-308G/A and Interleukin 8(IL-8)-251C/T Polymorphisms in Pulmonary Tuberculosis Patients from Congo %A Faust Ren谷 Okamba %A Prudence Spinelie Koumba Pambou %A Mandingha Kosso Etoka-Beka %A Brave Nzoussi %A Regis Gothard Bopaka %A Cyr Jonas Morabandza %A Gabriel Ahombo %J Open Journal of Immunology %P 1-13 %@ 2162-4526 %D 2023 %I Scientific Research Publishing %R 10.4236/oji.2023.131001 %X Background: Tuberculosis (TB) is one of the world＊s deadliest infectious diseases. Tumor necrosis factor-Alpha (TNF-汐) and Interleukin 8 (IL-8) are involved in the pathogenesis of pulmonary TB (PTB). However, the contribution of polymorphisms of these cytokines to PTB susceptibility needed more investigation across geographic regions and ethnic groups. Purpose: The aim of this study was to investigate the association of the TNF-汐-308 G/A and IL-8-251T/A polymorphisms with PTB risk in the Congolese population. Methods: This case-control study included 150 PTB patients and 160 control subjects. Blood samples were collected from all participants and were used for the TNF-汐-308 G/A and IL-8-251T/A genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Odds ratios (OR) were calculated to estimate the potential polymorphism associations. A P level of < 0.05 was considered significant. Results: A significant difference was found between PTB patients and controls regarding the TNF-汐-308AA genotype (P = 0.035) distribution. Moreover, this genotype was associated with risk to TB (OR = 7.19, 95% CI = 0.85 - 60.65, P = 0.035). The A allele was significantly more frequent in PTB patients than in controls, and was associated with risk to PTB (OR = 1.68, 95% CI = 1.05 - 2.68, P = 0.