%0 Journal Article
%T Chronic Lymphocytic Leukemia of <i>del</i> 17p in a Young Subject: About a Case and Reviewed a Literature
%A Amadou Djibrilla-Almoustapha
%A Moustapha Mamane-Brah
%A Moustapha Elhadj-Chefou
%A Maman Rabiou Bad¨¦
%A Faiza Abba-Ousmane
%A Fanta Ousseini
%A Oumoulkairou Abdoulaye-Soumana
%A Bad¨¦ Malam-Abdou
%J Open Journal of Blood Diseases
%P 103-109
%@ 2164-3199
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojbd.2022.124011
%X <strong>Objective:</strong><span style=\"font-family:;\" \"=\"\"> To report a case of Chronic Lymphoid Leukemia in a 28-year-old young
subject, with variable clinical features and a TP53 mutation, diagnosed and
followed up in the Onco-Hematology department of the HNN. <b>Observation:</b> 28-year-old patient, having consulted for polyadenopathy and physical asthenia,
whose clinical examination found a conscious patient, submaxillary,
laterocervical, axillary and inguinal lymphadenopathy, bilateral, symmetrical,
painless and non-compressive whose largest measures 3 cm in diameter.
Hepato-splenomegaly and epistaxis. Predominantly lymphocyte hyperleukocytosis,
immunophenotyping revealed low CD19+, CD5+, CD23+, CD20 monoclonal B lymphoid
proliferation. The Matutes score was 4. A karyotype showed a three-chromosome
translocation; the short arm of a</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\">chromosome 2, the long arm of </span><span style=\"font-family:;\" \"=\"\">a </span><span style=\"font-family:;\" \"=\"\">chromosome 11 and the long
arm of </span><span style=\"font-family:;\" \"=\"\">a </span><span style=\"font-family:;\" \"=\"\">chromosome 13,</span><span style=\"font-family:;\" \"=\"\"> and</span><span style=\"font-family:;\" \"=\"\"> a translocation between the long arm of </span><span style=\"font-family:;\" \"=\"\">a </span><span style=\"font-family:;\" \"=\"\">chromosome 6 and the long arm of </span><span style=\"font-family:;\" \"=\"\">a </span><span style=\"font-family:;\" \"=\"\">chromosome 18. A FISH
objectified a led 17p. The diagnosis of Binet Stage C CLL with positive <i>del</i> 17p and complex karyotype was
retained. Despite the poor prognosis, the R-C (Rituximab-Chlorambucil) protocol
was instituted with once-weekly transfusions. The patient is still alive in
partial clinical and biological remission. <b>Conclusion:</b> Despite
therapeutic progress, the presence of the deletion of chromosome 17p with TP53
mutation and the young age of the patient does not change the patient¡¯s
prognosis.</span>
%K Chronic Lymphocytic Leukemia
%K Young Subject
%K &lt
%K i&gt
%K del&lt
%K /i&gt
%K 17 p
%K HNN
%K Niger
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=121755