%0 Journal Article
%T Peripheral Blood Cytokines Levels in Senegalese Women with Cervical Cancer during Chemotherapy
%A Diop Maimouna
%A Folly Mawulolo Gaba
%A Doudou Georges Massar Niang
%A Doudou Diouf
%A Sidy Ka
%A Moustapha Mbow
%A Rokhaya Ndiaye Diallo
%A Maguette Sylla Niang
%A Mback¨¦ Sembene
%A Ahmadou Dem
%A Babacar Mbengue
%A Alioune Dieye
%J Open Journal of Immunology
%P 86-97
%@ 2162-4526
%D 2022
%I Scientific Research Publishing
%R 10.4236/oji.2022.124006
%X Cervical cancer is the leading cause of cancer deaths of women in
developing world. Several studies demonstrated evidences of inflammatory
cytokines implication in cancer progression including in initiation, promotion
and invasion by affecting the immune surveillance. Our aim was to measure blood
circulating pro- and anti-inflammatory cytokines levels, their profiles
according to treatment issue and relation with prognostic factors in cervical
cancer during chemotherapy. Blood samples were collected from a cohort of 35
cervical cancer women and 42 women healthy controls (HC) with no history of
malignancy. For each CP, three samples were taken at three-week intervals. The
first one (S1) was taken before initiation of the chemotherapy protocol. S2 and
S3 were samples collected respectively at day 21 and day 42. Cytokines levels
were evaluated by ELISA. Mean age of patients was 54.1 year (35 <span style=\"font-family:;\" \"=\"\">-</span><span style=\"font-family:;\" \"=\"\"> 77 yo). In groups, no relation
was observed between age and cytokines levels. Before chemotherapy, high levels
of IL-6, IL-4 and IFN-<i>¦Ã</i> were observed
in CP compared to HC (<i>p &lt; </i>0<i>.</i>001)<i> </i>and at the same period, IL-10 and TNF-<i>¦Á</i> levels were significantly low in CP (<i>p
&lt; </i>0<i>.</i>05) and<i> </i>negatively correlated (<i>r </i>=<i>&nbsp;¡ª</i>0<i>.</i>79;<i> p</i></span><i><span style=\"font-family:;\" \"=\"\"> </span></i><span style=\"font-family:;\" \"=\"\">=<i> </i>0<i>.</i>017). In this CP group,
IL-4 levels were positively correlated between S1 and S2 (<i>r </i>=<i> </i>0<i>.</i>72;<i> p</i></span><i><span style=\"font-family:;\" \"=\"\"> </span></i><span style=\"font-family:;\" \"=\"\">=<i> </i>0<i>.</i>002) and between S1 and S3 (<i>r </i>=<i> </i>0<i>.</i>74;<i> p </i>=<i> </i>0<i>.</i>019).
Similar correlations were observed for TNF-<i>¦Á</i> levels: S1/S2</span><span style=\"font-family:;\" \"=\"\"> </span><span style=\"font-family:;\" \"=\"\">(<i>r </i>=<i> </i>0<i>.</i>54;<i> p </i>=<i> </i>0<i>.</i>027), S2/S3 (<i>r </i>=<i> </i>0<i>.</i>82;<i> p </i>=<i> </i>0<i>.</i>009)
and S1/S3 (<i>r </i>=<i> </i>0<i>.</i>66;<i> p </i>=<i> </i>0<i>.</i>036) with a significant
increase of TNF-<i>¦Á</i> in blood during
treatment. Depending on chemotherapy¡¯s efficacy, CP patients were separated
into 1) non responders (NR), 2) partial responders (PR) and 3) good responders
(GR). Compared to PR and GR groups, NR patients showed: </span><span style=\"font-family:;\" \"=\"\">a</span><span style=\"font-family:;\" \"=\"\">) higher serum levels of
IL-6, IL-10
%K Cervical Cancer
%K Chemotherapy
%K Cytokines
%K Biomarkers
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=121765