%0 Journal Article
%T 昼夜节律与组织器官再生研究进展<br> Research Progress in Circadian Rhythm and Tissue and Organ Regeneration
%A 卢博文
%A 张书强
%A 徐绘
%J Bioprocess
%P 224-232
%@ 2164-5582
%D 2022
%I Hans Publishing
%R 10.12677/BP.2022.124026
%X 昼夜节律是生物体适应地球的昼夜交替而形成的一种周期性的生命活动现象。形成昼夜节律的生物钟通过调节多个下游基因的表达从而影响细胞增殖、内分泌和新陈代谢等许多生物学过程。对于昼夜节律的既往研究主要集中在生理和病理方向，然而其在组织器官再生中的角色尚不清楚。近年来，人们相继发现昼夜节律在多个组织器官的再生中发挥重要作用，并且在不同的系统中昼夜节律均有独特的调控再生的机制。本文综述了昼夜节律的分子机制及其调控肠道、皮肤和肝脏再生的研究进展。<br />
Circadian rhythm is the cyclic life activity formed by organisms adapting to the alternation of day and night on the earth. The circadian clock influences many biological processes such as cell proliferation, endocrine and metabolism by regulating the expression of multiple downstream genes. Previous studies on circadian rhythm mainly focused on its physiological and pathological roles, but its function in tissue and organ regeneration remains poorly understood. In recent years, researchers have found that circadian rhythm plays an important role in the regeneration of multi-ple tissues and organs, with unique mechanisms in each system. Here we summarize the molecular mechanism of circadian rhythm and the recent research progress in its role in intestinal, skin and liver regeneration.
%K 组织再生，昼夜节律，生物钟，增殖<br> Tissue Regeneration
%K Circadian Rhythm
%K Circadian Clock
%K Proliferation
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=58805