%0 Journal Article
%T 创伤性脊髓损伤修复过程中少突胶质细胞的作用<br> Oligodendrocytes and Its Role in Spinal Cord Traumatic Injury
%A 张小娇
%A 汤欣
%J Bioprocess
%P 205-212
%@ 2164-5582
%D 2022
%I Hans Publishing
%R 10.12677/BP.2022.124023
%X 临床上脊髓损伤对国家、社会和个人产生重大身体、心理和经济负担。脊髓损伤后，血脑屏障被破坏，血细胞渗入损伤部位，神经元和胶质细胞发生死亡，进而引起受损轴突的脱髓鞘病变，这一系列生理病理反应导致不可逆转的神经功能损伤。少突胶质细胞是中枢神经系统的髓鞘形成细胞，并且少突胶质前体细胞(oligodendrocyte precursor cells, OPCs)是已知的成熟少突胶质细胞唯一来源，具有保护损伤轴突的作用。本文将对少突胶质细胞在脊髓损伤后发生的生理病理变化，以及对其在脊髓损伤修复中发挥的作用的研究现状进行综述，并且对脊髓损伤修复未来发展方向进行展望。<br />
Spinal cord injury (SCI) is a severe emergency that causes personal physical, psychological problems and social economic burdens among individuals, communities and countries. In SCI, un-alterable neuronal dysfunction occurs due to a series of physiopathologic processes, including pen-etration of blood cells in the injury site following blood-brain barrier (BBB) disruption and demye-lination of injured axons following the apoptotic cascade of neuronal and glial cells. Oligodendro-cytes form the myelin sheaths in the central nervous system (CNS). Oligodendrocyte precursor cells (OPCs) are the main source of mature oligodendrocytes that protects neuronal axons from the inju-ry site. This literature review outlines the physiopathological traits of oligodendrocytes after SCI, summarizes recent research on its role in the traumatic spinal cord injury and repair, and demon-strates future efforts on the management of SCI.
%K 少突胶质细胞，脊髓损伤，神经再生<br> Oligodendrocyte
%K Spinal Cord Injury
%K Neural Regeneration
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=58802