%0 Journal Article
%T IgG Anti-Body Titers among Patients with Amoebic Liver Abscess in Bangui, Central African Republic
%A Wilfrid Sylvain Nambei
%A Edwige R¨¦gina Kodia-Lenguetama
%A Junior Nguerenam-Ouefio
%J Open Journal of Immunology
%P 77-85
%@ 2162-4526
%D 2022
%I Scientific Research Publishing
%R 10.4236/oji.2022.124005
%X <i>Entamoeba histolytica (Eh)</i> is a protozoan parasite that causes amoebiasis characterized by
intestinal damage and amoebic liver development and is an important cause of hospitalization in low-middle income
countries. The aims of this study were to determine the prevalence and the titer of IgG anti Eh in ALA (Amoebic Liver Abscess)
patients¡¯ in Bangui according sex, age and other risk factors. This was a cross
sectional study where data was collected between January 2018 and October 2020.
The diagnosis of ALA was suspected based on clinical symptoms of; fever,
abdominal pain (usually in the right hypochondrium or epigastrium) and clinical
signs of hepatomegaly and/or tender liver with or without jaundice and
abdominal ultra-sonography. ALA patients¡¯ IgG antibody titers were
measured by Indirect Hemmaglutination Assay and Chi-square test was used. A total of 1249 ALA
patients were included, among whom 570 (45.64%) were positive. Of these, 244
(42.08%) had titer 1:160 or less, 223 patients¡¯ (39.13%) had titer ranging from
1:320 to 1:640 and 103 patients (18.07%) had strong titer ranging from 1:1280
to 1:2560. The association between antibody titer results, age and sex was no
significant (p = 1.0000). Our findings indicate a high prevalence of ALA and
show no significant difference between the sex and age ALA patients.
%K Amoebic Liver Abscess
%K Antibody
%K Sex Difference
%K Central African Republic
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=121746