%0 Journal Article
%T Incidence of Sickle Cell Disease and Other Hemoglobinopathies in Burkina Faso: Results of a Five-Year Systematic Neonatal Screening (2015-2019) in Four Urban Hospitals
%A Salam Sawadogo
%A Koumpingnin Nebie
%A Donatien Kima
%A H¨¦l¨¨ne Traore Savadogo
%A Jean De Dieu Sanou
%A Dieudonn¨¦ Ouedraogo
%A Paul Ouedraogo
%A Hyacinthe Zamane
%A Abdoulaye Ndiaye
%A El¨¦onore Kafando
%J Open Journal of Blood Diseases
%P 87-97
%@ 2164-3199
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojbd.2022.124009
%X Hemoglobinopathies,
mainly Sickle cell disease (SCD), are the most common monogenic disorders in
Africa. In Burkina Faso, data on these diseases are scarce, mainly hospital-based in Ouagadougou and its
surroundings. In order to assess the incidence and allelic frequencies of the
main hemoglobinopathies in newborns in Burkina Faso, we conducted a
cross-sectional study from 2015 to 2019 in four hospitals. The study included
babies of both sexes, regardless of ethnic group and parents¡¯ hemoglobin
status. It was a newborn screening and hemoglobin variants were detected using
isoelectric focusing on cord blood samples and confirmed using hemoglobin
electrophoresis by high-performance liquid chromatography. The proportions
and cumulative incidences of the different hemoglobinopathies were computed.
Hardy-Weinberg equilibrium law was applied to calculate
genotypic and allelic frequencies. The significant level was p < 0.05. Out
of 11,337 newborns included, 47.8% were males and 60.2% were from Bobo-Dioulasso. Abnormal
hemoglobin was found in 27.1%, representing a cumulative incidence of 1:4
newborns. The incidence of SCD was 1.9% (1:53 newborns) with 27.9% of
homozygous SS. Homozygous CC and compound heterozygous C¦Â-Thalassemia accounted for 1.1%. SCD cases were 1.51 times higher
in Bobo-Dioulasso (OR = 1.51;
95% CI [1.09 - 2.10]: p = 0.013). The
observed genotype frequencies were significantly different from the expected
ones (p < 0.001). The ¦ÂS and ¦ÂC alleles represented 5.1 and 9.9%, respectively. This study showed
a high incidence of hemoglobinopathies. Such results raise the question of
control strategies for these hemoglobinopathies in our country.
%K Abnormal Hemoglobin
%K ¦Â-Globin Gene
%K Newborn Screening
%K Isoelectric Focusing
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=121228