%0 Journal Article
%T Influence of Some Physicochemical Exposure Factors on the Metronidazole Content of a Pharmaceutical Product: Flagyl® 250 mg Tablet
%A Mariette Desiree Yehe
%A Fr¨¦d¨¦rique Yah Marie-Pierre Nikiema
%A Linda H¨¦
%A Vincent De Paul Ovi
%A Jean-Kisito Kouame
%A Patrick Grah Atheba
%A Gildas Komenan Gbassi
%J Open Journal of Physical Chemistry
%P 31-45
%@ 2162-1977
%D 2022
%I Scientific Research Publishing
%R 10.4236/ojpc.2022.123003
%X The
present work aims to study the influence of some physicochemical parameters
(light, temperature, ethanol, bile salts, potassium hydroxide, hydrogen
peroxide) on the content of Metronidazole (MTZ) contained in the reference
substance (SR) and in a pharmaceutical specialty Flagyl<sup><span><span style=\"white-space:nowrap;\">&amp;#174;</span></span></sup><span style=\"font-family:;\" \"=\"\"> 250 mg
tablet (FLG). The method developed was linear and accurate in accordance with
USP 38 and the MTZ contents were obtained by UV-visible spectrophotometry at
278 nm. These contents ranged from 225 mg to 275 mg and were thus consistent
with the concentration present in the proprietary medicines (250 mg). The study
of the influence of physicochemical parameters on the MTZ content in SR and FLG
showed that MTZ contents are unstable in the presence of Ethanol at 96<span style=\"white-space:nowrap;\">&amp;#730;</span>, KOH at
0.1N and bile salts but also when the temperature is higher than 25<span style=\"white-space:nowrap;\">&amp;#730;</span>C. However,
they remain stable in the presence of light and H<sub>2</sub>O<sub>2</sub> and
undergo degradation in an acidic environment.</span>
%K Metronidazole
%K Influence
%K Physicochemistry
%K Content
%K Stability
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=120971