%0 Journal Article
%T 耐碳青霉烯类肺炎克雷伯菌的耐药现状及耐药机制研究<br>Drug Resistance Status and Mechanism of Carbapenem-Resistant Klebsiella pneumoniae
%A 刘昆
%A 李文强
%J Advances in Clinical Medicine
%P 9507-9513
%@ 2161-8720
%D 2022
%I Hans Publishing
%R 10.12677/ACM.2022.12101375
%X 肺炎克雷伯菌作为革兰氏阴性机会致病菌，常定植于人体口腔、呼吸道、胃肠道、泌尿道，是引起院内和社区获得性感染中重要的肠杆菌科。碳青霉烯类抗生素是治疗肺炎克雷伯菌感染的常用药物，然而，随着近年来临床上碳青霉烯类抗菌药物的广泛使用，耐碳青霉烯类肺炎克雷伯菌的患病率以惊人的速度上升，其多重耐药性正在成为一个日益严重的全球性问题，为临床治疗带来了巨大挑战。本文就近年来耐碳青霉烯类肺炎克雷伯菌的耐药现状及分子耐药机制进行综述，为预防及有效遏制该菌的传播提供依据。<br />
Klebsiella pneumoniae, as a gram-negative opportunistic pathogen, is often colonized in human oral cavity, respiratory tract, gastrointestinal tract and urinary tract. It is an important enterobacteri-aceae that causes nosocomial and community-acquired infections. Penicillium carbon alkene is an-tibiotic treatment of Klebsiella pneumoniae infection commonly used drugs, however, as in recent years, the clinical Penicillium carbon alkene the wide use of antimicrobial agents, resistance to car-bon Penicillium the prevalence of alkene pneumonia klebsiella bacteria rising at an alarming rate, its multiple drug resistance is becoming an increasingly serious global problem, has brought the huge challenge for clinical treatment. This article reviews the drug resistance status and molecular resistance mechanisms of carbapenem-resistant Klebsiella pneumoniae in recent years, so as to provide a basis for preventing and effectively curbing the spread of the bacteria.
%K 碳青霉烯类，肺炎克雷伯菌，耐药机制<br>Carbapenems
%K Klebsiella pneumoniae
%K Resistance Mechanisms
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=57022