%0 Journal Article
%T 电化学方法检测抗癌药物氟尿嘧啶的最新研究进展——新材料修饰电极助力提升检测效果<br>Recent Progress in Electrochemical Detection toward Anticancer Drug Fluorouracil—Detection Performance Improved by Novel Electrode Material
%A 刘泽馨
%A 柳俊屹
%A 刘宇轩
%A 黄显博
%A 李梦珂
%A 方芳
%A 钱昆
%J Hans Journal of Biomedicine
%P 295-304
%@ 2161-8984
%D 2022
%I Hans Publishing
%R 10.12677/HJBM.2022.124036
%X 5-氟尿嘧啶自合成以来，被广泛地应用于消化道癌和其他实体瘤的治疗。虽然获得了很好的疗效，然而，它的毒副作用也越来越引起科研人员的重视。为了进一步研究治疗过程中，该药在人群中产生的差异、以及环境污染与职业暴露对其的影响，我们总结了近年来5-氟尿嘧啶的检测方法，对比发现电化学检测凭借其检测限低，重现性好，预处理简单，实验操作简便等优势在众多方法中脱颖而出，特别是新型材料在修饰电极方面的应用，进一步提升了检测效果。<br />
5-fluorouracil has been widely used in the treatment of gastrointestinal cancer and other solid tumors since its synthesis. Although it has obtained good curative effect, its toxic and side effects have attracted more and more attention of researchers. In order to further study the difference of the drug in the population during the treatment process, as well as the impact of environmental pollution and occupational exposure, we summarized the detection methods of 5-fluorouracil in recent years, and found that electrochemical detection has stood out among many methods by virtue of its low detection limit, good reproducibility, simple pretreatment, simple experimental operation and other advantages, especially the application of new materials in modified electrodes, which further improved the detection effect.
%K 5-氟尿嘧啶，剂量管理，可检测浓度，电化学，电极材料<br>5-Fluorouracil
%K Dose Administration
%K Detectable Concentration
%K Electrochemistry
%K Electrode 
Materials
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=56914