%0 Journal Article
%T Efficacy and Safety of 30% Supramolecular Salicylic Acid Peeling Combined with Isotretinoin Erythromycin Gel in the Treatment of Moderate-to-Severe Acne Vulgaris: A Comparative Study
%A Jie Chen
%A Yusha Guo
%A Ying Wu
%A Xiaoqin Zhao
%A Jing Yang
%J International Journal of Clinical Medicine
%P 461-467
%@ 2158-2882
%D 2022
%I Scientific Research Publishing
%R 10.4236/ijcm.2022.1310033
%X <strong>Background: </strong>Both 30% supramolecular salicylic acid (SA) and isotretinoin erythromycin gel (IEG) have proven efficacy with good safety profiles in the treatment of acne vulgaris. <strong>Objectives:</strong> This study compared the clinical efficacy and safety of 30% SA peeling and IEG in the treatment of moderate-to-severe acne vulgaris. <strong>Methods:</strong> Patients with moderate-to-severe acne vulgaris were randomized into 3 groups of 30 persons each, and treated with SA peel, or IEG, or SA combine with IEG (SA + IEG group). Evaluation of acne was done by effective rate and individual lesion counts. And the adverse effects and recurrence were recorded.<strong> Results:</strong> The SA + IEG group was better in clinical efficacy and treating noninflammatory and inflammatory lesions than that of single treatment group (P &lt; 0.05). No serious adverse effects were recorded. There were no significant differences in adverse effects and recurrence between groups (P &gt; 0.05). <strong>Conclusion:</strong> 30% SA combined with IEG had a significant effect in the treatment of moderate-to-severe acne lesions.
%K 30% Supramolecular Salicylic Acid
%K Isotretinoin Erythromycin Gel
%K Moderate-to-Severe Acne Vulgaris
%K Efficacy
%K The Adverse Reactions
%K Recurrence Rate
%U http://www.scirp.org/journal/PaperInformation.aspx?PaperID=120631